Wide Sexual Dimorphism of Hepatocellular Carcinoma Presentation in Algeria

Autor: Rachid Ould Gougam, Pascal Pineau, Maroua Bendaoud, Salima Cheraitia, Hocine Asselah, Yazid Chikhi, Aïcha Bensalem, S. Berkane, Fadila Lounes, Mustapha Lahcene, Sonia Ait Younes, Nassila Belal, Chahrazed Zemmouchi
Přispěvatelé: Department of Internal medicine and Gastroenterology [Bologhine - Alger, Algeria], University Hospital Bologhine-EPH - Établissement Public Hospitalier Ibn Ziri [Bologhine - Alger, Algeria], Hôpital militaire d'Aïn Naadja / hôpital central de l'armée (HCA), Department of Radiology [Bologhine - Alger, Algeria], EPH - Établissement Public Hospitalier Ibn Ziri [Bologhine - Alger, Algeria], Department of Pathology [Hussein Dey, Algeria], EPH Parnet-CHU Nafissa Hamoud de Hussein Dey (ex-Parnet) [Hussein Dey, Algeria], Institut Pasteur d'Algérie, Réseau International des Instituts Pasteur (RIIP), Hôpital Mustapha [Mustapha, Algeria], Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Gastrointest Tumors
Gastrointestinal Tumors
Gastrointestinal Tumors, 2019, 6 (3-4), pp.122-136. ⟨10.1159/000501453⟩
ISSN: 2296-3774
Popis: Hepatocellular carcinoma (HCC) represents a worrying public health problem in North Africa and particularly in Egypt. The situation is unclear in western North Africa where HCC has been rarely submitted to careful scrutiny. We decided to analyze demographic, biochemical, virological, and clinical data of a series of HCC from Algerian patients to establish the landscape of this tumor in the country. In the present work, we described 337 cases of primary liver cancer from Bologhine Hospital in Algiers, the capital of Algeria. The mean age of patients was 63.8 ± 11.4 years with a male:female sex ratio of 1.5. The most prevalent risk factors were hepatitis C, hepatitis B, and metabolic pathologies (type 2 diabetes and obesity). The mean BMI was 25.6 ± 4.7 at tumor diagnosis. A strong duality of risk factors and tumor presentation between male and female patients was apparent. Women tended to be older (mean 65.4 vs. 62.7 years, p = 0.039) and either seropositive for anti-HCV (60.0 vs. 41.6%, p = 0.0018) resulting primarily from tattoos and/or scarification (47.2 vs. 25.7%, p = 1.0 × 10–4) or more often affected by metabolic disorders (mean BMI 26.1 ± 0.7 vs. 25.1 ± 0.5, p = 0.0248) commonly associated with personal antecedents of cholecystectomy (21.2 vs. 5.8%, p = 4.4 × 10–5). By contrast, men were younger, poorer survivors (mean 9.3 vs. 13.3 months, p = 0.005), more frequently HBsAg carriers (27.8 vs. 10.5%, p = 4.8 × 10–5), and more exposed to lifestyle risk factors such as smoking (39.4 vs. 3.0%, p = 3.9 × 10–16) or alcohol use (19.1 vs. 0.7%, 1.5 × 10–8). Finally, geographic disparities throughout Algeria were reminiscent of the situation of chronic hepatitis C in the country. A significant excess of cases originated from the region of Batna, Eastern Algeria, already known for its high rate of hepatitis C. Our results suggest that due to culture or sex-dependent biological differences, the tumor process affecting the liver is drastically different between sexes in Algeria.
Databáze: OpenAIRE
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