Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort

Autor: Rial, Manuel J., Álvarez-Puebla, Maria J., Arismendi, Ebymar, Caballero, María L., Cañas, José A., Cruz Carmona, María Jesús, González-Barcala, Francisco-Javier, Luna-Porta, Juan-Alberto, Martínez Rivera, Carlos, Mullol, Joaquim, Muñoz, Xavier, Olaguibel, José M., Picado, César, Plaza, Vicente, Quirce, Santiago, Romero-Mesones, Christian, Salgado, Francisco-Javier, Sastre, Beatriz, Soto-Retes, Lorena, Valero, Antonio, Valverde, Marcela, Sastre, Joaquín, del Pozo, Victora, Universitat Autònoma de Barcelona
Přispěvatelé: Institut Català de la Salut, [Rial MJ] Servicio de Alergología, Departamento de Inmunología, Instituto de Investigación Sanitaria (IIS) Fundación Jiménez Díaz, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain. [Álvarez-Puebla MJ] Servicio de Alergología, Complejo Hospitalario de Navarra, Pamplona, Spain. [Arismendi E] CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Servicio de Neumología y Alergia, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain. [Caballero ML] Servicio de Alergia, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. [Cañas JA] Servicio de Alergología, Departamento de Inmunología, Instituto de Investigación Sanitaria (IIS) Fundación Jiménez Díaz, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain. CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. [Cruz MJ, Muñoz X] CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Departament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
Rok vydání: 2021
Předmět:
Asma - Diagnòstic - Espanya
Pulmonary function testing
030207 dermatology & venereal diseases
0302 clinical medicine
Other subheadings::/diagnosis [Other subheadings]
Immunology and Allergy
Medicine
Spanish: asma
biomarcadores
asma eosinofílica
inflamación
asma neutrofílica
fenotipos
medicine.diagnostic_test
Asma - Estudi de casos
Asma eosinofílica
Asma neutrofílica
Geographic Locations::Europe::Spain [GEOGRAPHICALS]
Phenotype
Cohort
Biomarker (medicine)
características del estudio::estudio multicéntrico [CARACTERÍSTICAS DE PUBLICACIONES]
Cohort study
Pulmonary and Respiratory Medicine
medicine.medical_specialty
phenotype
Immunology
Otros calificadores::/diagnóstico [Otros calificadores]
eosinophilic asthma
Physical examination
03 medical and health sciences
Internal medicine
Fenotipos
Asma
Asthma
Inflammation
localizaciones geográficas::Europa (continente)::España [DENOMINACIONES GEOGRÁFICAS]
Bronchiectasis
Inflamación
business.industry
Research
biomarkers
Respiratory Tract Diseases::Bronchial Diseases::Asthma [DISEASES]
RC581-607
asthma
medicine.disease
neutrophilic asthma
Study Characteristics::Multicenter Study [PUBLICATION CHARACTERISTICS]
respiratory tract diseases
Biomarcadores
030228 respiratory system
inflammation
Exhaled nitric oxide
enfermedades respiratorias::enfermedades bronquiales::asma [ENFERMEDADES]
Immunologic diseases. Allergy
Eosinophilic asthma
business
Biomarkers
Neutrophilic asthma
Zdroj: Scientia
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Clinical and Translational Allergy
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Clinical and Translational Allergy, Vol 11, Iss 1, Pp n/a-n/a (2021)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
ISSN: 2045-7022
Popis: Asthma; Inflammation; Phenotype Asma; Inflamación; Fenotipos Asma; Inflamació; Fenotips Introduction The MEGA (MEchanism underlying the Genesis and evolution of Asthma) project is a multicenter cohort study carried out in eight Spanish hospitals, gathering clinical, physiological, and molecular data from patients with asthma and multimorbidities in order to gain insight into the different physiopathological mechanisms involved in this disorder. Material and Methods We report the baseline clinical and physiological characteristics and biomarker measures of adult participants in the project with the aim of better understanding the natural history and underlying mechanisms of asthma as well as the associated multimorbidities across different levels of severity. We carried out a detailed clinical examination, pulmonary function testing, measurement of fractional exhaled nitric oxide (FeNO), blood counts, induced sputum, skin prick tests, chest computed tomography scan, asthma questionnaires, and multimorbidity assessment in 512 asthmatic patients. Results When compared to patients with milder disease, severe asthmatic patients showed greater presence of symptoms, more exacerbations, lower asthma control, increased airflow obstruction, and higher frequency of chronic rhinosinusitis with nasal polyps, severe rhinitis, anxiety and depression, gastroesophageal reflux, and bronchiectasis. Conclusion The MEGA project succeeded in recruiting a high number of asthma patients, especially those with severe disease, who showed lower control and higher frequency of multimorbidities. This study was supported by Sanofi [02/055], Fondo de Investigación Sanitaria–FIS [PI15/00803], [PI15/01900], the Merck Health Foundation, CIBER de Enfermedades Respiratorias (CIBERES), a Carlos III Institute of Health initiative, and FEDER funds. The authors recognize Oliver Shaw, English editor of IIS-FJD, for his revision and editing of the manuscript, and Ignacio Mahillo-Fernández for statistical revision.
Databáze: OpenAIRE
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