Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort
Autor: | Rial, Manuel J., Álvarez-Puebla, Maria J., Arismendi, Ebymar, Caballero, María L., Cañas, José A., Cruz Carmona, María Jesús, González-Barcala, Francisco-Javier, Luna-Porta, Juan-Alberto, Martínez Rivera, Carlos, Mullol, Joaquim, Muñoz, Xavier, Olaguibel, José M., Picado, César, Plaza, Vicente, Quirce, Santiago, Romero-Mesones, Christian, Salgado, Francisco-Javier, Sastre, Beatriz, Soto-Retes, Lorena, Valero, Antonio, Valverde, Marcela, Sastre, Joaquín, del Pozo, Victora, Universitat Autònoma de Barcelona |
---|---|
Přispěvatelé: | Institut Català de la Salut, [Rial MJ] Servicio de Alergología, Departamento de Inmunología, Instituto de Investigación Sanitaria (IIS) Fundación Jiménez Díaz, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain. [Álvarez-Puebla MJ] Servicio de Alergología, Complejo Hospitalario de Navarra, Pamplona, Spain. [Arismendi E] CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Servicio de Neumología y Alergia, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain. [Caballero ML] Servicio de Alergia, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. [Cañas JA] Servicio de Alergología, Departamento de Inmunología, Instituto de Investigación Sanitaria (IIS) Fundación Jiménez Díaz, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain. CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. [Cruz MJ, Muñoz X] CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Departament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
Rok vydání: | 2021 |
Předmět: |
Asma - Diagnòstic - Espanya
Pulmonary function testing 030207 dermatology & venereal diseases 0302 clinical medicine Other subheadings::/diagnosis [Other subheadings] Immunology and Allergy Medicine Spanish: asma biomarcadores asma eosinofílica inflamación asma neutrofílica fenotipos medicine.diagnostic_test Asma - Estudi de casos Asma eosinofílica Asma neutrofílica Geographic Locations::Europe::Spain [GEOGRAPHICALS] Phenotype Cohort Biomarker (medicine) características del estudio::estudio multicéntrico [CARACTERÍSTICAS DE PUBLICACIONES] Cohort study Pulmonary and Respiratory Medicine medicine.medical_specialty phenotype Immunology Otros calificadores::/diagnóstico [Otros calificadores] eosinophilic asthma Physical examination 03 medical and health sciences Internal medicine Fenotipos Asma Asthma Inflammation localizaciones geográficas::Europa (continente)::España [DENOMINACIONES GEOGRÁFICAS] Bronchiectasis Inflamación business.industry Research biomarkers Respiratory Tract Diseases::Bronchial Diseases::Asthma [DISEASES] RC581-607 asthma medicine.disease neutrophilic asthma Study Characteristics::Multicenter Study [PUBLICATION CHARACTERISTICS] respiratory tract diseases Biomarcadores 030228 respiratory system inflammation Exhaled nitric oxide enfermedades respiratorias::enfermedades bronquiales::asma [ENFERMEDADES] Immunologic diseases. Allergy Eosinophilic asthma business Biomarkers Neutrophilic asthma |
Zdroj: | Scientia Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Clinical and Translational Allergy r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Clinical and Translational Allergy, Vol 11, Iss 1, Pp n/a-n/a (2021) r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol |
ISSN: | 2045-7022 |
Popis: | Asthma; Inflammation; Phenotype Asma; Inflamación; Fenotipos Asma; Inflamació; Fenotips Introduction The MEGA (MEchanism underlying the Genesis and evolution of Asthma) project is a multicenter cohort study carried out in eight Spanish hospitals, gathering clinical, physiological, and molecular data from patients with asthma and multimorbidities in order to gain insight into the different physiopathological mechanisms involved in this disorder. Material and Methods We report the baseline clinical and physiological characteristics and biomarker measures of adult participants in the project with the aim of better understanding the natural history and underlying mechanisms of asthma as well as the associated multimorbidities across different levels of severity. We carried out a detailed clinical examination, pulmonary function testing, measurement of fractional exhaled nitric oxide (FeNO), blood counts, induced sputum, skin prick tests, chest computed tomography scan, asthma questionnaires, and multimorbidity assessment in 512 asthmatic patients. Results When compared to patients with milder disease, severe asthmatic patients showed greater presence of symptoms, more exacerbations, lower asthma control, increased airflow obstruction, and higher frequency of chronic rhinosinusitis with nasal polyps, severe rhinitis, anxiety and depression, gastroesophageal reflux, and bronchiectasis. Conclusion The MEGA project succeeded in recruiting a high number of asthma patients, especially those with severe disease, who showed lower control and higher frequency of multimorbidities. This study was supported by Sanofi [02/055], Fondo de Investigación Sanitaria–FIS [PI15/00803], [PI15/01900], the Merck Health Foundation, CIBER de Enfermedades Respiratorias (CIBERES), a Carlos III Institute of Health initiative, and FEDER funds. The authors recognize Oliver Shaw, English editor of IIS-FJD, for his revision and editing of the manuscript, and Ignacio Mahillo-Fernández for statistical revision. |
Databáze: | OpenAIRE |
Externí odkaz: |