Effectiveness of an absorbable fibrin sealant patch to reduce lymphoceles formation after axillary lymphadenectomy for breast cancer: a matched-pair analysis
| Autor: | Irene Gomez-Luque, Pilar Rioja-Torres, Rubén Ciria-Bru, Sebastián Rufián-Peña, Elena Navarro-Rodríguez, Javier Briceño-Delgado, Juan Ruiz-Rabelo, Marina Álvarez-Benito, Guillermo Bascuñana-Estudillo, Nélida Díaz-Jiménez |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Lymphocele Matched-Pair Analysis Breast Neoplasms Fibrin Tissue Adhesive Adenocarcinoma Postoperative Complications Breast cancer medicine Humans Aged Aged 80 and over business.industry Incidence (epidemiology) Carcinoma Ductal Breast Thrombin Fibrinogen General Medicine TachoSil Odds ratio Middle Aged medicine.disease Confidence interval Surgery Carcinoma Lobular Drug Combinations Logistic Models Treatment Outcome Axillary Lymphadenectomy Axilla Multivariate Analysis Lymph Node Excision Female Absorbable Fibrin Sealant Patch business |
| Zdroj: | The American Journal of Surgery. 208:824-830 |
| ISSN: | 0002-9610 |
| Popis: | This study evaluated the use of TachoSil as an adjunctive therapy for reducing axillary lymphocele formation.Eighty-six patients diagnosed with breast cancer N+ and treated with axillary lymphadenectomy received a TachoSil patch in the axillary wound. Using a database of patients without placing a hemostatic patch, we applied a matched case-control in a 1-to-2 fashion. Multiple and logistic regression analyses were used to evaluate postoperative results.Patient group with TachoSil showed a significantly lower drainage volume (P.001) and the length of stay was significantly shorter (P.001). The number of patients with evacuative punctures was 24.5% in the group with patch versus 51.2% in the control group (P.001). In multivariate analysis, the use of TachoSil was a significant predictor of reducing axillary drainage volume (P .001), mean length of hospital stay (P = .001), and number of evacuative punctures of lymphocele (odds ratio .264, 95% confidence interval .144 to .484, P.001).The use of TachoSil in axillary lymphadenectomy may be a safe and useful treatment option for reducing axillary drainage volume, incidence of symptomatic lymphocele, and hospital stay. |
| Databáze: | OpenAIRE |
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