Polymorphisms in DNA repair genes in lung cancer patients living in a coal-mining region
| Autor: | Elena N. Voronina, Varvara I. Minina, A. N. Glushkov, Maxim Yu. Sinitsky, Olga A. Soboleva, Victor A. Titov, Anastasia V. Ryzhkova, Yana A. Savchenko, Ruslan A. Titov, M. L. Bakanova |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Lung Neoplasms Epidemiology Polymorphism Single Nucleotide Mining Russia XRCC2 03 medical and health sciences XRCC1 0302 clinical medicine XRCC3 Internal medicine Occupational Exposure medicine Biomarkers Tumor Humans Genetic Predisposition to Disease 030212 general & internal medicine Lung cancer Multifactor dimensionality reduction business.industry Incidence Public Health Environmental and Occupational Health Odds ratio Middle Aged medicine.disease Prognosis APEX1 DNA Repair Enzymes 030220 oncology & carcinogenesis Case-Control Studies ERCC2 Female business Follow-Up Studies |
| Zdroj: | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 28(6) |
| ISSN: | 1473-5709 |
| Popis: | Air pollutants and ionizing radiation are well-known carcinogens involved in the pathogenesis of lung cancer, and residents of coal-mining regions are exposed routinely to these agents. Polymorphisms in DNA repair genes may be associated with an increased risk of malignant transformation. We investigated associations between the risk of lung cancer in residents of the coal-mining region and polymorphisms in the genes APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489, rs25487), XRCC2 (rs3218536), XRCC3 (rs861539), ADPRT/PARP1 (rs1136410), XPD/ERCC2 (rs13181), XPG/ERCC5 (rs17655), XPC (rs2228001), ATM (rs1801516), and NBS1 (rs1805794). Three hundred and forty residents of the Kemerovo Region (a coal-mining region of western Siberia) were lung cancer patients exposed to air pollutants and ionizing radiation (case) and 335 were healthy donors (control). Genotyping was performed by real-time PCR and allele-specific PCR. We discovered that polymorphisms in the XPD gene in men [log-additive model: odds ratio (OR) = 1.64, 95% confidence interval (CI): 1.17-2.31], the ATM gene in women and nonsmokers (codominant model: OR = 0.11, 95% CI: 0.02-0.49 and OR = 0.25, 95% CI: 0.08-0.72, respectively), the APEX1 gene for smokers (recessive model: OR = 2.55, 95% CI: 1.34-4.85), and the NBS1 gene for those who work in the coal industry (overdominant model: OR = 0.40, 95% CI: 0.21-0.75) are associated with an increased risk of lung cancer. Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655). These results indicate an association between combinations of polymorphisms in the studied genes and the risk of lung cancer in residents of a coal-mining region. |
| Databáze: | OpenAIRE |
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