Delivery of drugs into brain tumors using multicomponent silica nanoparticles
| Autor: | Gil Covarrubias, Ramamurthy Gopalakrishnan, S. Raghunathan, Pubudu M. Peiris, Abdelrahman Rahmy, Kathleen Tong, Mark A. Griswold, Morgan E Lorkowski, T Ouyang, A Yun, Efstathios Karathanasis, Vindya S. Perera, Peter Bielecki, Ketan B. Ghaghada, Oguz Turan |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Drug
media_common.quotation_subject Brain tumor Nanoparticle Mice Nude 02 engineering and technology 010402 general chemistry Blood–brain barrier 01 natural sciences Ferric Compounds Article Mice Glioma Cell Line Tumor medicine Distribution (pharmacology) Animals General Materials Science media_common Drug Carriers Chemistry Brain Neoplasms Mesoporous silica 021001 nanoscience & nanotechnology medicine.disease Silicon Dioxide 0104 chemical sciences medicine.anatomical_structure Blood-Brain Barrier Drug delivery Biophysics Nanoparticles Female 0210 nano-technology |
| Zdroj: | Nanoscale |
| Popis: | Glioblastomas are highly lethal cancers defined by resistance to conventional therapies and rapid recurrence. While new brain tumor cell-specific drugs are continuously becoming available, efficient drug delivery to brain tumors remains a limiting factor. We developed a multicomponent nanoparticle, consisting of an iron oxide core and a mesoporous silica shell that can effectively deliver drugs across the blood-brain barrier into glioma cells. When exposed to alternating low-power radiofrequency (RF) fields, the nanoparticle's mechanical tumbling releases the entrapped drug molecules from the pores of the silica shell. After directing the nanoparticle to target the near-perivascular regions and altered endothelium of the brain tumor via fibronectin-targeting ligands, rapid drug release from the nanoparticles is triggered by RF facilitating wide distribution of drug delivery across the blood-brain tumor interface. |
| Databáze: | OpenAIRE |
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