MetabolicN-oxidation of α-acetylenic amines—A gas chromatographic mass spectrometric investigation of the chemical decomposition ofN-(5-pyrrolidinopent-3-ynyl)succinimideN'-oxide using deuterium substitution
| Autor: | Gösta Hallström, Björn Lindeke |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Chromatography
Oxide Biochemistry Mass spectrometric Decomposition Gas Chromatography-Mass Spectrometry Pyrrolidinones Rats chemistry.chemical_compound Deuterium Succinimide chemistry Microsomes Liver Animals Molecular Medicine Organic chemistry N oxidation Electron impact mass spectrometry Spectroscopy Chemical decomposition |
| Zdroj: | Biological Mass Spectrometry. 8:514-520 |
| ISSN: | 1096-9888 1052-9306 |
| DOI: | 10.1002/bms.1200081010 |
| Popis: | On gas chromatographic analysis, N-(5-pyrrolidinopent-3-ynyl)succinimide N'-oxide gave rise to three main decomposition products, which were assigned the structures N-(3-oxopent-4-enyl)succinimide, N-(penta-3, 4-dienyl)succinimide and N-3(3-pyrrolidino-3-oxopropyl)succinimide. These three products were identified by electron impact mass spectrometry, using deuterium substituted N-oxides, and mechanisms for the formation of the former two are proposed. By gas chromatographic mass spectrometric analysis, extracts from metabolic incubation of N-(5-pyrrolidinopent-3-ynyl)succinimide were shown to contain the N-oxide, as previously indicated by indirect methods. |
| Databáze: | OpenAIRE |
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