Supplementary Figure 5 from Akt Inhibitors MK-2206 and Nelfinavir Overcome mTOR Inhibitor Resistance in Diffuse Large B-cell Lymphoma

Autor: Samir Parekh, Joseph A. Sparano, B. Hilda Ye, Melissa J. Fazzari, Shanisha Gordon, Netha Ulahannan, Venu K. Thirukonda, Bing Xia, Pei-Yu Kuo, Violetta Leshchenko, Adam M. Petrich
Rok vydání: 2023
Popis: PDF file - 26K, Simultaneous inhibition of mTOR and AKT pathways is synergistic in Breast cancer cell lines. A-B. Shown here are normalized isobolograms of treatment effects of Rapamycin and MK-2206, in the above cell lines. Proportion of MK-2206 IC50 is shown on the X-axis, and proportion of Rapamycin IC50 are shown on the Y-axis. Points at or near the red line are indicative of additive effects of the two agents; those below the line are indicative of synergistic effects.
Databáze: OpenAIRE