Long-term durability of immune responses after hepatitis A vaccination among HIV-infected adults
| Autor: | Kenneth Wilkins, Anthony D. Grosso, Mark R. Wallace, Anuradha Ganesan, William P. Bradley, Brian K. Agan, Carolyn Brandt, Andrew W. Lee, Stephanie O. Klopfer, Michael L. Landrum, Nancy F. Crum-Cianflone, Jason D. Maguire, Amy C. Weintrob |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty viruses Hepatitis A vaccine Population HIV Infections Antibodies Viral Immunoglobulin G Major Articles and Brief Reports Immunity Internal medicine medicine Immunology and Allergy Humans education Retrospective Studies education.field_of_study Hepatitis A Vaccines biology business.industry Hepatitis A virus diseases Retrospective cohort study biochemical phenomena metabolism and nutrition medicine.disease Confidence interval United States CD4 Lymphocyte Count Vaccination Infectious Diseases Military Personnel Immunology biology.protein Linear Models Female business |
| Zdroj: | The Journal of infectious diseases. 203(12) |
| ISSN: | 1537-6613 |
| Popis: | Background. Vaccination provides long-term immunity to hepatitis A virus (HAV) among the general population, but there are no such data regarding vaccine durability among human immunodeficiency virus (HIV)‐ infected adults. Methods. We retrospectively studied HIV-infected adults who had received 2 doses of HAV vaccine. We analyzed blood specimens taken at 1 year, 3 years, and, when available, 6‐10 years postvaccination. HAV immunoglobulin G (IgG) values of R10 mIU/mL were considered seropositive. Results. We evaluated specimens from 130 HIV-infected adults with a median age of 35 years and a median CD4 cell count of 461 cells/mm 3 at or before time of vaccination. Of these, 49% had an HIV RNA load ,1000 copies/mL. Initial vaccine responses were achieved in 89% of HIV-infected adults (95% confidence interval [CI], 83%‐94%), compared with 100% (95% CI, 99%‐100%) of historical HIV-uninfected adults. Among initial HIVinfected responders with available specimens, 90% (104 of 116; 95% CI, 83%‐95%) remained seropositive at 3 years and 85% (63 of 74; 95% CI, 75%‐92%) at 6‐10 years. Geometric mean concentrations (GMCs) among HIVinfected adults were 154, 111, and 64 mIU/mL at 1, 3, and 6‐10 years, respectively, compared with 1734, 687, and 684 mIU/mL among HIV-uninfected persons. Higher GMCs over time among HIV-infected adults were associated with lower log10 HIV RNA levels (b 52 .12, P 5 .04). Conclusions. Most adults with well-controlled HIV infections had durable seropositive responses up to 6‐10 years after HAV vaccination. Suppressed HIV RNA levels are associated with durable HAV responses. |
| Databáze: | OpenAIRE |
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