Selective culture of Escherichia coli to prevent infective complications of transrectal ultrasound‐guided prostate biopsy: Clinical efficacy and analysis of characteristics of quinolone‐resistant Escherichia coli

Autor:	Hitoshi Tachiki, Yasuharu Kunishima, Naoki Itoh, Takaoki Hirose, Naoya Masumori, Hiroshi Hotta, Teruhisa Uehara, Masahiro Yanase, Satoshi Takahashi, Masanori Matsukawa, Yoshiki Hiyama, Koji Ichihara, Jiro Hashimoto, Keisuke Taguchi, Koh Takeyama
Rok vydání:	2019
Předmět:	Image-Guided Biopsy Male Sitafloxacin medicine.medical_specialty Prostate biopsy Urology 030232 urology & nephrology Levofloxacin Microbial Sensitivity Tests Quinolones Meropenem Gastroenterology 03 medical and health sciences 0302 clinical medicine Japan Internal medicine Drug Resistance Bacterial Escherichia coli medicine Humans Prospective Studies Escherichia coli Infections Ultrasonography Interventional Aged Aged 80 and over medicine.diagnostic_test business.industry Prostate Rectum Acute prostatitis Antibiotic Prophylaxis medicine.disease Antimicrobial Ultrasound-Guided Prostate Biopsy Anti-Bacterial Agents Logistic Models Treatment Outcome Amikacin 030220 oncology & carcinogenesis business Fluoroquinolones medicine.drug
Zdroj:	International Journal of Urology. 26:655-660
ISSN:	1442-2042 0919-8172
DOI:	10.1111/iju.13960
Popis:	Objectives To evaluate a regimen of targeted prophylaxis using rectal swab culture in patients undergoing transrectal ultrasound-guided prostate biopsy, and to investigate the characteristics of isolated fluoroquinolone-resistant Escherichia coli. Methods A prospective study was carried out from June 2013 through December 2014. Rectal swabs were cultured on agar plates containing either 2 μg/mL levofloxacin or 1 μg/mL sitafloxacin before transrectal ultrasound-guided prostate biopsy. Patients with susceptible organisms received levofloxacin or sitafloxacin, whereas those with resistant organisms received directed antimicrobial prophylaxis according to the results of the antimicrobial susceptibility test. Patients with infectious complications after prostate biopsy were identified, and characteristics of patients carrying fluoroquinolone-resistant Escherichia coli were analyzed. Results A total of 397 men underwent transrectal ultrasound-guided prostate biopsy. Of these patients, 74 (18.6%) had fluoroquinolone-resistant Escherichia coli. All fluoroquinolone-resistant Escherichia coli were susceptible to amikacin and meropenem. The risk factor for possible fluoroquinolone-resistant Escherichia coli was age of ≥73 years. Three (0.7%) patients who received appropriate antimicrobial prophylaxis had high-grade fever after the prostate biopsy. However, the pathogens were not fluoroquinolone-resistant Escherichia coli. Conclusions Targeted antimicrobial prophylaxis in patients undergoing transrectal ultrasound-guided prostate biopsy can be associated with reducing severe infectious complications caused by fluoroquinolone-resistant Escherichia coli.
Databáze:	OpenAIRE
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