Segmental Liver Stiffness Evaluated with Magnetic Resonance Elastography Is Responsive to Endovascular Intervention in Patients with Budd-Chiari Syndrome
| Autor: | Muhammad Umair Sami, Kai Xu, Haitao Ge, Lulu Lyu, Panpan Liu, Chunfeng Hu, Peng Xu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Budd-Chiari syndrome
Adult Male Intraclass correlation 030218 nuclear medicine & medical imaging 03 medical and health sciences Liver disease 0302 clinical medicine Liver stiffness medicine Humans Endovascular treatment Radiology Nuclear Medicine and imaging In patient Aspartate Aminotransferases business.industry Endovascular Procedures Alanine Transaminase Repeatability Middle Aged medicine.disease Magnetic resonance elastography Liver 030220 oncology & carcinogenesis Gastrointestinal Imaging Budd–Chiari syndrome Elasticity Imaging Techniques Original Article Female Nuclear medicine business |
| Zdroj: | Korean Journal of Radiology |
| ISSN: | 2005-8330 1229-6929 |
| DOI: | 10.3348/kjr.2018.0767 |
| Popis: | Objective To assess segmental liver stiffness (LS) with MRI before and after endovascular intervention in patients with Budd-Chiari syndrome (BCS). Materials and methods Twenty-three patients (13 males and 10 females; mean age, 42.6 ± 12.6 years; age range, 31-56 years) with BCS as a primary liver disease were recruited for this study. Two consecutive magnetic resonance elastography (MRE) examinations were performed before the endovascular treatment. Fifteen patients who underwent endovascular intervention treatment also had follow-up MRE scans within three days after the procedure. LS was measured in three liver segments: the right posterior, right anterior, and left medial segments. Inter-reader and inter-exam repeatability were analyzed with intraclass correlation coefficients (ICCs) and Bland-Altman analysis. Segmental LS and clinical characteristics before and after the intervention were also compared. Results Within three days of the endovascular intervention, all three segmental LS values decreased: LS of the right posterior segment = 7.23 ± 0.88 kPa (before) vs. 4.94 ± 0.84 kPa (after), LS of the right anterior segment = 7.30 ± 1.06 kPa (before) vs. 4.77 ± 0.85 kPa (after), and LS of the left medial segment = 7.22 ± 0.87 kPa (before) vs. 4.87 ± 0.72 kPa (after) (all p = 0.001). There was a significant correlation between LS changes and venous pressure gradient changes before and after treatments (r = 0.651, p = 0.009). The clinical manifestations of all 15 patients significantly improved after therapy. The MRE repeatability was excellent, with insignificant variations (inter-reader, ICC = 0.839-0.943: inter-examination, ICC = 0.765-0.869). Bland-Altman analysis confirmed excellent agreement (limits of agreement, 13.4-19.4%). Conclusion Segmental LS measured by MRE is a promising repeatable quantitative biomarker for monitoring the treatment response to minimally invasive endovascular intervention in patients with BCS. |
| Databáze: | OpenAIRE |
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