Cell-penetrating, amphipathic cyclic peptoids as molecular transporters for cargo delivery
| Autor: | Min Hyeon Shin, Yeongju Lee, Hyun-Soo Kim, Hyun-Suk Lim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cell
Intracellular Space Peptide Cell-Penetrating Peptides 010402 general chemistry 01 natural sciences Permeability Catalysis Peptoids Amphiphile Materials Chemistry medicine Humans Biological evaluation chemistry.chemical_classification 010405 organic chemistry Chemistry Metals and Alloys Transporter General Chemistry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials medicine.anatomical_structure Ceramics and Composites Biophysics Hydrophobic and Hydrophilic Interactions Intracellular |
| Zdroj: | Chemical Communications. 57:6800-6803 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | Here we describe the design, synthesis, and biological evaluation of cell-penetrating, amphipathic cyclic peptoids as a novel class of molecular transporters. We demonstrated that macrocyclization, along with the introduction of hydrophobic residues, greatly enhanced cellular uptake of polyguanidine linear peptoids. The amphipathic cyclic peptoids showed an order of magnitude more efficient intracellular delivery ability, compared to a commonly used polyarginine cell-penetrating peptide, representing one of the best molecular transporters reported to date. Given the excellent cell-permeability, proteolytic stability, and ease of synthesis, the amphipathic cyclic peptoids would be broadly applicable to a wide range of clinical and biological applications. |
| Databáze: | OpenAIRE |
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