Significance of miR-27a and miR-31 in early diagnosis and prognosis of colorectal cancer
| Autor: | Qingjun Cui |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Colorectal cancer Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Biopsy medicine Carcinoma Mucinous carcinoma Clinical significance miR-31 rectal cancer miR-27a medicine.diagnostic_test business.industry Cancer Articles medicine.disease mir-31 030104 developmental biology Oncology colon cancer 030220 oncology & carcinogenesis Colorectal Polyp business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1074 |
| Popis: | Clinical significance of micro-ribonucleic acid (miR)-27a and miR-31 in the early diagnosis and prognosis of colorectal cancer were investigated. Forty patients with colorectal malignancy admitted to Xintai People's Hospital from February 2014 to April 2018 were enrolled as the observation group, of which 30 patients were diagnosed via pathological biopsy. Another 40 patients diagnosed with colorectal polyp and receiving surgical treatment were selected as the control group. The relative amount of miR-27a and miR-31 was measured. The relative expression levels of miR-27a and miR-31 in patients were analyzed. The diagnostic sensitivity, specificity and accordance rates of positive miR-27a and miR-31 expression in colorectal cancer were recorded. The correlation of the relative expression levels of miR-27a and miR-31 with the survival time of patients were analyzed. In the observation group, the relative expression levels of miR-27a and miR-31 in patients with lymph node metastasis and distant metastasis were higher than those in patients without lymph node metastasis and distant metastasis (P |
| Databáze: | OpenAIRE |
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