Anti-angiogenic and anti-tumor apoptotic activities of a topoisomerase II inhibiting agent SJ-8026
| Autor: | Chung Sun-Gan, Yung-Jin Kim, Eui-Yeun Yi, Dong-Wook Kang, Park Si-Kyung, Sun-Hwan Lee, Cho Eui-Hwan, Ho-Seok Kwon, Joo Jeong-Ho, Eun-Joo Jeong |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Cancer Research Programmed cell death Angiogenesis Angiogenesis Inhibitors Antineoplastic Agents Apoptosis Biology Neovascularization Mice medicine Animals Humans Topoisomerase II Inhibitors Enzyme Inhibitors Cells Cultured Cell Proliferation Tube formation Matrigel Caspase 3 Cytochromes c Angiogenesis inhibitor Mice Inbred C57BL Chorioallantoic membrane Oncology Caspases Cancer research Acridines Cattle medicine.symptom |
| Zdroj: | International journal of oncology. 26(6) |
| ISSN: | 1019-6439 |
| Popis: | A new piperazine derivative, SJ-8026, is a synthetic anti-cancer agent which exhibits topoisomerase II-inhibiting activities. In this study, we investigated the possibility that this compound inhibits angiogenesis and induces tumor-cell apoptosis using bovine aortic endothelial cells (BAECs) and human hepatocellular carcinoma cells (HepG2) as a model system. in vivo, SJ-8026 decreased the neovascularization of chick embryos and the basic fibroblast growth factor-induced angiogenesis in the chorioallantoic membrane and the mouse Matrigel implants. in vitro, SJ-8026 treatment resulted in the inhibition of proliferation, migration, invasion and tube formation in BAECs. In addition, the treatment of SJ-8026 in HepG2 cells reduced the cell viability, and caused the production of fragmented DNA and the morphological changes corresponding to apoptosis including condensed and fragmented DNA. SJ-8026 also elicited the release of cytochrome c and the activation of caspase-3. Therefore, it is possible that SJ-8026 functions as both angiogenesis inhibitor and apoptosis inducer. Taken together, these results suggest that SJ-8026 may be a candidate for strong anti-cancer agent with the ability to inhibit the angiogenesis of endothelial cells and to induce the apoptosis of tumor cells. |
| Databáze: | OpenAIRE |
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