Association of PER2 and CRY1 Polymorphisms with the Morningness-Eveningness in Korean Adults
Autor: | In Bum Suh, Se Yong Lee, Seong Jae Kim, Jun-Won Hwang, Jung Hie Lee |
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Rok vydání: | 2015 |
Předmět: |
Pulmonary and Respiratory Medicine
endocrine system medicine.medical_specialty Period (gene) Endogeny Biology Morningness-eveningness lcsh:RC321-571 Cancer risk Rhythm Physiology (medical) Internal medicine medicine Circadian rhythm lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Korean adults Suprachiasmatic nucleus PER2 CLOCK Psychiatry and Mental health Endocrinology Neurology CRY1- 2790T/G Neurology (clinical) Casein kinase 1 PER2-2221A/G |
Zdroj: | Sleep Medicine Research, Vol 6, Iss 2, Pp 60-65 (2015) |
ISSN: | 2233-8853 2093-9175 |
Popis: | Background and Objective Individuals have a unique circadian preference, which is based on differences in endogenous rhythm and environmental factors. There has been no study on the relationship between the morningness-eveningness (ME) preference and the polymorphisms of PER2 and CRY1 genes, which may play an essential role in the modulation of circadian rhythm. Our present study aims to examine the difference in the polymorphisms of PER2-2221A/G and CRY1-2790T/G, which are related to a greater cancer risk, according to the ME preference. Methods The Korean version of the Morningness-Eveningness Questionnaire was administered and buccal DNA samples were obtained from 425 Korean adults aged 18 years or older. We excluded subjects who were being treated for sleep disorders or those with shift work. 47 morning type (MT) (age: 44.57 ± 12.33, M:F = 14:33) subjects, 59 neither type (NT) (age: 35.20 ± 9.53, M:F = 20:39) subjects and 51 evening type (ET) (age: 28.80 ± 8.03, M:F = 14:37) subjects were finally included in the present study. The above candidate single nucleotide polymorphisms were analyzed by DNA sequencing or a SNaPshot assay. Results For the PER2-2221A/G and CRY1-2790T/G, there were no significant differences in the genotype distribution, allele frequency, or proportion of G allele positive subjects between the MT and ET groups. There was no significant difference in the mean scores of the MEQ-K, KESS, or PSQI between G allele positive and negative subjects for either PER2-A2221A/G or CRY1-2790T/G. Conclusions Our study did not support the association of the ME preference with the PER2-2221 A/G and CRY1-2790T/G in Korean adults. |
Databáze: | OpenAIRE |
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