Disrupted axon-glia interactions at the paranode in myelinated nerves cause axonal degeneration and neuronal cell death in the aged Caspr mutant mouse shambling
| Autor: | Yoshiharu Murata, Yoshiko Takagishi, Hiroyuki Mizoguchi, Kimiaki Katanosaka |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging Programmed cell death Neurofilament Central nervous system Action Potentials In Vitro Techniques Biology Nerve Fibers Myelinated 03 medical and health sciences 0302 clinical medicine medicine Animals Axon Neurons Cell Death General Neuroscience Neurodegeneration medicine.disease Sciatic Nerve Axons Mice Mutant Strains Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure nervous system Peripheral nervous system Nerve Degeneration Neuroglia Neurology (clinical) Sciatic nerve Geriatrics and Gerontology Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Neurobiology of Aging. 43:34-46 |
| ISSN: | 0197-4580 |
| Popis: | Emerging evidence suggests that axonal degeneration is a disease mechanism in various neurodegenerative diseases and that the paranodes at the nodes of Ranvier may be the initial site of pathogenesis. We investigated the pathophysiology of the disease process in the central and peripheral nervous systems of a Caspr mutant mouse, shambling (shm), which is affected by disrupted paranodal structures and impaired nerve conduction of myelinated nerves. The shm mice manifest a progressive neurological phenotype as mice age. We found extensive axonal degeneration and a loss of neurons in the central nervous system and peripheral nervous system in aged shm mice. Axonal alteration of myelinated nerves was defined by abnormal distribution and expression of neurofilaments and derangements in the status of phosphorylated and non/de-phosphorylated neurofilaments. Autophagy-related structures were also accumulated in degenerated axons and neurons. In conclusion, our results suggest that disrupted axon-glia interactions at the paranode cause the cytoskeletal alteration in myelinated axons leading to neuronal cell death, and the process involves detrimental autophagy and aging as factors that promote the pathogenesis. |
| Databáze: | OpenAIRE |
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