Phenotype standardization for immune-mediated drug-induced skin injury
| Autor: | Mariam Molokhia, Bruce Carleton, Peter S. Friedmann, Emma C. Phillips, Pascal Demoly, Catherine H. Smith, M. Papaluca-Amati, L. La Grenade, Neil H. Shear, Yoon K. Loke, Munir Pirmohamed |
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| Rok vydání: | 2011 |
| Předmět: |
Drug
Pathology medicine.medical_specialty media_common.quotation_subject Drug Hypersensitivity 03 medical and health sciences 0302 clinical medicine Immune system Epidemiology medicine Animals Humans Pharmacology (medical) 030304 developmental biology media_common Pharmacology 0303 health sciences business.industry medicine.disease Acute generalized exanthematous pustulosis Dermatology Phenotype Toxic epidermal necrolysis 3. Good health Patient recruitment Pharmacogenomics Stevens-Johnson Syndrome business 030217 neurology & neurosurgery |
| Zdroj: | Clinical Pharmacology & Therapeutics |
| ISSN: | 1532-6535 |
| Popis: | Advances in genetic research and molecular biology techniques have made it possible to begin to characterize the underlying genetic factors that predispose patients to serious forms of drug-induced skin injury (DISI). To facilitate research in this area, we have set out standardized phenotypic definitions for (i) Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), (ii) acute generalized exanthematous pustulosis (AGEP), and (iii) hypersensitivity syndrome (HSS; also known as drug reaction with eosinophilia and systemic symptoms (DRESS) and drug-induced hypersensitivity syndrome (DIHS)). A DISI Expert Working Group comprising participants with varied expertise reviewed and debated current terminology and diagnostic criteria for DISI and agreed on the minimum phenotypic criteria for selected forms of DISI (SJS/TEN, AGEP, and HSS). In addition, an algorithm has been developed to aid appropriate clinical categorization of patients with DISI. These standardized criteria will be important in facilitating adequate and accurate patient recruitment in order to advance research in pharmacogenomic, immunological, mechanistic, and epidemiological studies. |
| Databáze: | OpenAIRE |
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