Identification of a novel HLA-DRB1 allele (HLA-DRB1*111902*)
| Autor: | Y.Z. Jiang, D. Zhang, L. Li, D. Wang, C.Z. Zhao, D.P. Lu, G.X. Lan, D. Jiang, Dianqing Li, T. Guo, B. Cai, G.Y. Sun, Y.H. Liu, H.F. Gao, Z. Li, X. Liu |
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| Rok vydání: | 2005 |
| Předmět: |
Male
musculoskeletal diseases China Molecular Sequence Data Immunology Biology Biochemistry Exon immune system diseases Sequence Homology Nucleic Acid Genetics Humans Immunology and Allergy Nucleotide Allele skin and connective tissue diseases HLA-DRB1 Alleles Polymerase Sequence (medicine) chemistry.chemical_classification Base Sequence Nomenclature Committee Oligonucleotide Nucleic Acid Hybridization Exons HLA-DR Antigens General Medicine Molecular biology Leukemia Myeloid Acute chemistry biology.protein HLA-DRB1 Chains |
| Zdroj: | Tissue Antigens. 66:67-68 |
| ISSN: | 1399-0039 0001-2815 |
| Popis: | In this paper, we report a new HLA-DRB1 allele identified in a male acute myeloid leukaemia Chinese patient. This sample was initially typed as DRB1*11XX using commercial polymerase chain reaction-sequence-specific primers kit. When it was typed using a chip-based sequence-specific oligonucleotide technique, a novel hybridization pattern that does not match any known alleles was observed. Through sequencing, we have identified this allele as a new HLA-DRB1 allele, which was later named HLA-DRB1*111902 by the WHO Nomenclature Committee. The sequence of this new allele differs from DRB1*111901 by one nucleotide (from G to C) at 203nt of exon 2 but does not cause any amino acid substitution. |
| Databáze: | OpenAIRE |
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