Variation in antral follicle counts at different times in the menstrual cycle: does it matter?

Autor: Elizabeth Burt, Ali Al Chami, Ephia Yasmin, L Webber, George Ploubidis, Dimitrios Mavrelos, Vikram Sinai Talaulikar
Rok vydání: 2016
Předmět:
Adult
Anti-Mullerian Hormone
Risk
0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
media_common.quotation_subject
Ovarian hyperstimulation syndrome
Fertilization in Vitro
Andrology
Ovarian Hyperstimulation Syndrome
03 medical and health sciences
0302 clinical medicine
Ovarian Follicle
Ovulation Induction
Follicular phase
Odds Ratio
Humans
Medicine
Ovarian follicle
Menstrual Cycle
Menstrual cycle
media_common
Observer Variation
Gynecology
030219 obstetrics & reproductive medicine
biology
business.industry
Obstetrics and Gynecology
Anti-Müllerian hormone
medicine.disease
Antral follicle
Fertility
030104 developmental biology
Concordance correlation coefficient
medicine.anatomical_structure
Reproductive Medicine
biology.protein
Female
Ovulation induction
Follicle Stimulating Hormone
business
Infertility
Female
Gonadotropins
Developmental Biology
Zdroj: Reproductive BioMedicine Online. 33:174-179
ISSN: 1472-6483
DOI: 10.1016/j.rbmo.2016.04.012
Popis: Antral follicle count (AFC) variation was examined across the menstural cycle and its effect on clinical management assessed. In 79 women, AFC was documented in early (iAFC) and late follicular phase (sAFC). Absolute agreement between iAFC and sAFC and agreement for classification into categories of risk of extremes of ovarian response were examined. Ovarian stimulation protocols designed with iAFC and sAFC, and the predictive value of iAFC and sAFC for extremes of ovarian response, were compared in women undergoing ovarian stimulation. Significant differences were found between iAFC and sAFC (16 [IQR 9-24] versus 13 [IQR 7- 21]; P = 0.001), with moderate agreement for the classification into at risk of extremes of response (k = 0.525). Agreement for protocol selection based on either AFC (k = 0.750) and starting gonadotrophin dose was good (concordance correlation coefficient 0.970 [95% CI 0.951 to 0.982]). Predictive value for iAFC and sAFC was maintained for poor ovarian response and risk of ovarian hyperstimulation syndrome (OR 0.634 [0.427 to 0.920], 0.467 [0.233 to 0.935]) and (OR 1.049 [0.974 to 1.131], 1.140 [1.011 to 1.285]). Across the cycle, AFC varies but does not significantly affect ovarian stimulation protocol design and prediction of extreme ovarian response.
Databáze: OpenAIRE
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