The Investigation of the Calcium Metabolism Changes in Rheumatic Mitral Valve Patients

Autor:	Resit Coskun, Süleyman Karakoyun, Muhammet Bugra Karaaslan, Metin Çağdaş, Tahir Bezgin, Aziz Inan Celik
Rok vydání:	2022
Předmět:	Calcium metabolism medicine.medical_specialty medicine.anatomical_structure business.industry Mitral valve Internal medicine medicine Cardiology Medicine General Medicine business Mitral valve parathyroid hormone vitamin D inflammation Tıp
Zdroj:	Volume: 25, Issue: 1 50-57 Koşuyolu Heart Journal
ISSN:	2149-2980 2149-2972
DOI:	10.51645/khj.2021.m131
Popis:	Introduction: Rheumatic mitral valve disease (RMVD) is associated with autoimmune heart valve injury. Parathyroid hormone (PTH) and vitamin D are two essential molecules that have effects on the immune system. In this study, we aimed to evaluate the relationship between PTH and vitamin D in patients with RMVD. Patients and Methods: We investigated 81 patients with RMVD and 75 healthy subjects. According to Wilkins score, baseline clinical, laboratory, and echocardiographic parameters were recorded, and all RMVD patients were analyzed. Multivariate logistic regression analysis was performed between the groups. Results: Vitamin D levels were significantly low in the RMVD group. Patients were stratified according to Wilkins score [Wilkins score Conclusion: This study showed that vitamin D levels were low in patients with RMVD. According to the Wilkins score, PTH levels were significantly high in patients with a high Wilkins score. Changes in PTH and vitamin D levels may trigger inflammation and be responsible for valve damage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a277cac30c8c898c8b21b13ba860f97 https://doi.org/10.51645/khj.2021.m131 Zobrazit plný text záznamu