Prognostic Value of Tumor-Infiltrating FoxP3+ T Cells in Gastrointestinal Cancers: A Meta Analysis

Autor: Peng Wang, Fengmei Wang, Huaiwei Liao, Yingtang Gao, Yong Zhang, Yong Huang, Rongfa Yuan, Zhi Du
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Oncology
Male
Pathology
Colorectal cancer
lcsh:Medicine
Gene Expression
Pathology and Laboratory Medicine
Biochemistry
White Blood Cells
Animal Cells
Adenocarcinomas
Gastrointestinal Cancers
Medicine and Health Sciences
Odds Ratio
lcsh:Science
Multidisciplinary
T Cells
Liver Diseases
Liver Neoplasms
Colon Adenocarcinoma
FOXP3
Forkhead Transcription Factors
Prognosis
Research Design
Hepatocellular carcinoma
Meta-analysis
Physical Sciences
Female
Cellular Types
Colorectal Neoplasms
Statistics (Mathematics)
Research Article
medicine.medical_specialty
Carcinoma
Hepatocellular
Clinical Research Design
Immune Cells
Immunology
Gastroenterology and Hepatology
Biostatistics
Research and Analysis Methods
Carcinomas
Rectal Cancer
Lymphocytes
Tumor-Infiltrating
Diagnostic Medicine
Stomach Neoplasms
Internal medicine
Gastrointestinal Tumors
Carcinoma
medicine
Humans
Statistical Methods
Survival analysis
Blood Cells
business.industry
lcsh:R
Biology and Life Sciences
Cancers and Neoplasms
Odds ratio
Cell Biology
Hepatocellular Carcinoma
medicine.disease
Survival Analysis
digestive system diseases
Confidence interval
Gastric Cancer
lcsh:Q
Clinical Immunology
Neoplasm Recurrence
Local
business
Biomarkers
Mathematics
Meta-Analysis
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 5, p e94376 (2014)
ISSN: 1932-6203
Popis: PURPOSE: Tumor-infiltrating FoxP3+ T cells have been reported in various human tumors, which impaired cell-mediated immunity and promoted disease progression. However, its prognostic value for survival in patients with different gastrointestinal cancers [hepatocellular carcinoma (HCC), colorectal cancer (CRC), gastric cancer (GC)] remains controversial. METHODS: Relevant literature was searched using PubMed, Embase, Cochrane, Ovid Medline and Chinese wanfang databases. A meta-analysis was conducted to estimate pooled survival and recurrence ratios. The odds ratio (OR) and 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. RESULTS: For HCC and GC, the overall survival at 1, 3 and 5-year of high FoxP3+ T cells infiltration patients were lower than low FoxP3+ T cells infiltration patients (P0.05). CONCLUSIONS: Our findings suggested that tumor-infiltrating FoxP3+ T cells were a factor for a poor prognosis for HCC and GC, but a good prognosis for CRC.
Databáze: OpenAIRE
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