Effect of timing of cefuroxime dosage on its protection of rats against gentamicin nephrotoxicity

Autor:	G. G. Patterson, R. M. Atkinson, I. W. Harman, J. M. Wheeldon, D. A. H. Pratt, R. D. Foord, K. Capel-Edwards
Rok vydání:	1980
Předmět:	Microbiology (medical) Male Cefuroxime Time Factors business.industry General Medicine Kidney Once daily treatment Nephrotoxicity Cephalosporins Rats Infectious Diseases Anesthesia Medicine Animals Gentamicin Kidney Diseases Gentamicins business medicine.drug
Zdroj:	Infection. 8(1)
ISSN:	0300-8126
Popis:	The neophrotoxic effect on rats of once daily treatment with 40 or 45 mg gentamicin/kg/day for ten days was substantially reduced by administration of 4 g cefuroxime/kg/day, either at the same time or eight hours later. This dosage of cefuroxime was protective when given for only two consecutive days starting on the first to third days of gentamicin treatment, but enhanced gentamicin nephrotoxocity when started on the sixth or subsequent days.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a250ad28e43e26aa6a78d7e665ed615 https://pubmed.ncbi.nlm.nih.gov/7372356 Zobrazit plný text záznamu Full text from SpringerLink