Physiological and Pharmacological Effects of Glucocorticoids on the Gastrointestinal Tract
| Autor: | N. I. Yarushkina, Ludmila Filaretova, T. T. Podvigina |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Somatic pain Corticosterone Drug Discovery medicine Gastric mucosa Humans Stomach Ulcer Glucocorticoids Pathological Dexamethasone Gastrointestinal tract business.industry medicine.anatomical_structure chemistry Gastric Mucosa Prednisolone 030211 gastroenterology & hepatology business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery medicine.drug Hormone |
| Zdroj: | Current Pharmaceutical Design. 26:2962-2970 |
| ISSN: | 1381-6128 |
| Popis: | The review considers the data on the physiological and pharmacological effects of glucocorticoids on the gastric mucosa and focuses on the gastroprotective role of stress-produced glucocorticoids as well as on the transformation of physiological gastroprotective effects of glucocorticoids to pathological proulcerogenic consequences. The results of experimental studies on the re-evaluation of the traditional notion that stress-produced glucocorticoids are ulcerogenic led us to the opposite conclusion suggested that these hormones play an important role in the maintenance of the gastric mucosal integrity. Exogenous glucocorticoids may exert both gastroprotective and proulcerogenic effects. Initially, gastroprotective effect of dexamethasone but not corticosterone, cortisol or prednisolone can be transformed into proulcerogenic one. The most significant factor for the transformation is the prolongation of its action rather the dose. Gastrointestinal injury can be accompanied by changes in somatic pain sensitivity and glucocorticoids contribute to these changes playing a physiological and pathological role. |
| Databáze: | OpenAIRE |
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