Moderate Procedural Sedation and Opioid Analgesia During Transradial Coronary Interventions to Prevent Spasm
| Autor: | Michael W. Cleman, Loukas K. Pappas, Charalambos Kossyvakis, Vlasios Pyrgakis, Georgios Giannopoulos, Dimitrios Avramides, Georgios Hahalis, Spyridon Deftereos, Christodoulos Stefanadis, Dimitrios Alexopoulos, Vasiliki Panagopoulou, Andreas Kaoukis, Konstantinos Raisakis |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Visual analogue scale business.industry medicine.medical_treatment Sedation Percutaneous coronary intervention Surgery law.invention Fentanyl Randomized controlled trial law medicine.artery Anesthesia medicine Midazolam Radial artery medicine.symptom Prospective cohort study business Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | JACC: Cardiovascular Interventions. 6(3):267-273 |
| ISSN: | 1936-8798 |
| DOI: | 10.1016/j.jcin.2012.11.005 |
| Popis: | Objectives The aim of this study was to test the hypothesis that moderate procedural sedation can reduce the incidence of radial artery spasm. Background Transradial access for left heart catheterization and percutaneous coronary intervention is increasingly used for emergent and elective procedures, in lieu of the femoral approach. However, increased rates of access site crossover have been reported, with radial artery spasm being a major contributor to this effect. Methods Patients undergoing elective transradial percutaneous coronary intervention were prospectively randomized to receive fentanyl and midazolam during the procedure or no treatment (control subjects). The primary endpoint was angiographically confirmed radial artery spasm. Patient discomfort was quantified with a visual analogue scale. Results Two thousand thirteen patients (age 64.5 ± 8.4 years) were randomized. Spasm occurred in 2.6% of the treatment group versus 8.3% of control subjects (p Conclusions Routine administration of relatively low doses of an opioid/benzodiazepine combination during transradial interventional procedures is associated with a substantial reduction in the rate of spasm, the need for access site crossover, and the procedure-related level of patient discomfort. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|