Murine influenza virus encephalomyelitis
| Autor: | Donald H. Harter, Konrad C. Hsu, Eugenia T. Gamboa, Philip E. Duffy |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
viruses
Encephalomyelitis Viral antigen Biology Defective virus Virus Pathology and Forensic Medicine Mice Cellular and Molecular Neuroscience Viral Interference medicine Animals Infective virus Antigens Viral Vaccination Cell degeneration Age Factors Brain Defective Viruses Orthomyxoviridae medicine.disease Virology Interferon production Influenza A virus Interfering virus Nerve Degeneration Interferons Neurology (clinical) Neuroglia |
| Zdroj: | Acta Neuropathologica. 34:157-169 |
| ISSN: | 1432-0533 0001-6322 |
| DOI: | 10.1007/bf00684666 |
| Popis: | Defective interfering influenza virus particles lessened the yield of infective virus recovered from brain after intracerebral challange of 3-week old mice, but failed to affect the appearance of disease or lethality. In 7-week old mice, the presence of defective interfering influenza virus particles reduced both lethality and virus yield. Viral inocula containing significant numbers of defective particles appeared to diminish later inflammatory changes, nerve cell degeneration and the appearance of viral antigen in deeper cerebral regions. The protective effect exerted by defective virus particles does not appear related to interferon production in brain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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