Zinc sulphate administered by transdermal iontophoresis improves breaking strength of surgical wounds in skin of alloxan-induced diabetic rats
| Autor: | Mauricio Ferraz de Arruda, Amanda Natália Lucchesi, César Tadeu Spadella, Pedro Colli Rocha Dias, Lucas Langoni Cassettari |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp), IMES-FAFICA |
| Rok vydání: | 2013 |
| Předmět: |
Male
surgical wound Time Factors medicine.medical_treatment Scars postoperative period chemistry.chemical_compound Random Allocation Diabetes mellitus Alloxan hydroxyproline rat glucose Transdermal Skin Surgical wound iontophoresis Iontophoresis skin scar Treatment Outcome Anesthesia medicine.symptom strength insulin medicine.medical_specialty RD1-811 animal experiment Wound healing Administration Cutaneous surgical technique Diabetes Mellitus Experimental Hydroxyproline male Tensile Strength medicine Animals controlled study Rats Wistar Astringents glycosylated hemoglobin Wound Healing nonhuman business.industry animal model Insulin Reproducibility of Results zinc sulfate electrode medicine.disease Zinc Sulfate Surgery Rats chemistry Wounds and Injuries business |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Acta Cirurgica Brasileira, Volume: 28, Issue: 8, Pages: 601-606, Published: AUG 2013 Acta Cirurgica Brasileira, Vol 28, Iss 8, Pp 601-606 (2013) Acta Cirúrgica Brasileira v.28 n.8 2013 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| ISSN: | 1678-2674 |
| Popis: | Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:30:06Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:32:49Z : No. of bitstreams: 1 2-s2.0-84881041244.pdf: 2331443 bytes, checksum: e47b4c049f52dff7335eeb1ae0e9f09d (MD5) Made available in DSpace on 2014-05-27T11:30:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-08-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Purpose: To investigate the effect of zinc sulphate administered by transdermal iontophoresis (TDI) on mechanical resistance of surgical wounds performed in the skin of diabetic rats. Methods: One hundred and sixty male Wistar rats weighing approximately 250g were submitted to an incision surgery at the anterior region of abdomen and randomly distributed into four experimental groups with 40 non-diabetic control animals (G1) and 40 untreated diabetic animals (G2), both without any treatment of incisions; 40 non-diabetic animals (G3) and 40 untreated diabetic animals (G4), both with incisions treated with zinc sulphate, administered for a period of four consecutive days after surgery, in sessions of ten minutes duration, using a continuous-current electrostimulator (Zn + TDI). Each experimental group was further divided into four subgroups with ten rats each to be evaluated on the 4th, 7th, 14th, and 21st day after surgery. In each period were analyzed clinical and laboratory from the animals, and measured the breaking strength and hydroxyproline content (OH-P) of the skin scars. RESULTS: Breaking strength (BS) was significantly reduced (p |
| Databáze: | OpenAIRE |
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