Effect of chloroquine and O,O'-bis(diethylaminoethyl)hexestrol on acidic phospholipid membranes
| Autor: | Karl-Heinz Hille, Hildegard Debuch, Achim Harder |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Phase transition temperature
Hexestrol Chemical Phenomena Phospholipid Temperature Chloroquine Phosphatidylglycerols Pulmonary Surfactants Hydrogen-Ion Concentration Biochemistry Medicinal chemistry Dissociation constant chemistry.chemical_compound Chemistry Membrane chemistry Amphiphile Liposomes medicine lipids (amino acids peptides and proteins) Calcium medicine.drug |
| Zdroj: | Hoppe-Seyler's Zeitschrift fur physiologische Chemie. 364(8) |
| ISSN: | 0018-4888 |
| Popis: | The amphiphilic drugs chloroquine and O,O'-bis(diethylaminoethyl)hexestrol are able to form complexes with the acidic-phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol. The dissociation constants of the complexes with chloroquine are independent of pH in the range investigated here (4--7) as well as of temperature (4 degrees C--40 degrees C). The phase transition temperature of phospholipid is markedly reduced by both drugs, the effect is reversible by addition of Ca2. |
| Databáze: | OpenAIRE |
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