Tenoxicam: acute dose-dependent disposition studies in rats
| Autor: | L. G. Lopez-Bustamante, D. Fos, J.I.F. Troconiz |
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| Rok vydání: | 1993 |
| Předmět: |
Volume of distribution
Male Total plasma Dose-Response Relationship Drug Chemistry Anti-Inflammatory Agents Non-Steroidal Pharmaceutical Science Blood Proteins Pharmacology Blood proteins Rats Piroxicam Pharmacokinetics Tenoxicam Injections Intravenous medicine Dose group Animals Acute dose Steady state (chemistry) Rats Wistar Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | Journal of pharmaceutical sciences. 82(8) |
| ISSN: | 0022-3549 |
| Popis: | Single intravenous bolus doses of tenoxicam of 2.5, 5, and 10 mg/kg were administered to male Wistar rats to determine the effects of dose on tenoxicam pharmacokinetics. Predicted apparent volume of distribution at steady state (Vdss) and total plasma clearance (CL) were, respectively, 42 and 45% higher in the animals given 10-mg/kg dose than the animals given 2.5- and 5-mg/kg doses. Binding of tenoxicam to plasma proteins showed saturability, with a 33% higher unbound fraction of tenoxicam in plasma when total drug concentration in plasma was 36 mg/L (high dose group) in comparison with animals given the low doses (12 and 20 mg/L). The blood-to-plasma concentration ratio of tenoxicam was concentration independent and therefore did not account for the observed dose-dependent changes in Vdss and CL. |
| Databáze: | OpenAIRE |
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