Analysis of Protrusio Acetabuli Using a CT-based Diagnostic Method in Korean Patients with Marfan Syndrome: Prevalence and Association with Other Manifestations
| Autor: | Seung-Hwa Lee, Chang-Seok Ki, Shin Yi Jang, Seung-Hyuk Choi, Jeong Hoon Yang, Duk Kyung Kim, Kwang Jin Chun, June Huh, Tae Young Chung, Sung Mok Kim, Hye Bin Gwag, Kiick Sung, Yeon Hyeon Choe |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male musculoskeletal diseases Marfan syndrome congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Adolescent Protrusio acetabuli Cardiovascular Disorders Comorbidity macromolecular substances Sensitivity and Specificity Marfan Syndrome Young Adult Aortic aneurysm Computed Tomography Aneurysm Risk Factors Republic of Korea Prevalence medicine Humans cardiovascular diseases skin and connective tissue diseases Ectopia lentis FBN1 Mutation Protrusio Acetabuli Aged Aged 80 and over Aortic dissection medicine.diagnostic_test business.industry Reproducibility of Results Acetabulum General Medicine Middle Aged medicine.disease Aortic Aneurysm Angiography Original Article Female Radiology Tomography X-Ray Computed business |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| DOI: | 10.3346/jkms.2015.30.9.1260 |
| Popis: | A new CT-based diagnostic method of protrusio acetabuli (PA) was introduced. However, prevalence of PA by this method and correlation between PA and other manifestations of Marfan syndrome (MFS) is unknown in Korean MFS patients. This study aimed to investigate the prevalence of PA diagnosed by a CT-based method in Korean patients with MFS, the association of PA with other manifestations of MFS, and the contribution of PA to MFS diagnosis. We retrospectively reviewed the records of 146 MFS patients with the presence of a causative FBN1 mutation and 146 age- and sex-matched controls from a single tertiary care center. All MFS patients underwent a complete assessment of criteria based on the revised Ghent nosology. PA was assessed quantitatively using a CT-based circle-wall distance (CWD) method. PA was diagnosed in 77.4% of patients in the MFS group and in 11.0% of the control group. CWD was significantly different between the two groups (1.50 mm vs. -0.64 mm, P |
| Databáze: | OpenAIRE |
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