Major diabetes-related vascular events do not improve glycaemic control in a population-based cohort of type 1 diabetic individuals
| Autor: | Lars Melholt Rasmussen, Trine Mejnert Jørgensen, Anders Green, Anne Katrin Sjølie, Mads Nybo, Jakob Grauslund |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Population Clinical Biochemistry Cohort Studies Internal medicine Diabetes mellitus Epidemiology medicine Humans education Stroke Event (probability theory) Glycated Hemoglobin Type 1 diabetes education.field_of_study business.industry Cancer General Medicine Middle Aged medicine.disease Surgery Diabetes Mellitus Type 1 Hyperglycemia Cohort Female business Diabetic Angiopathies |
| Zdroj: | Mejnert Jørgensen, T, Grauslund, J, Sjølie, A K, Green, A, Rasmussen, L M & Nybo, M 2009, ' Major diabetes-related vascular events do not improve glycaemic control in a population-based cohort of type 1 diabetic individuals ', Scandinavian Journal of Clinical & Laboratory Investigation, vol. 69, no. 7, pp. 748-751 . https://doi.org/10.3109/00365510903108410 |
| ISSN: | 0036-5513 |
| Popis: | Udgivelsesdato: 2009-Jul-6 Objective: It is known that sudden serious events alter life styles related to treatment efficiency, as for example in cancer patients. However, it has not been specifically addressed if a first-time diabetes-related clinical event has impact on glycaemic regulation. We therefore assessed this in a population-based cohort of patients with long-term type 1 diabetes. Methods: This study was based on a cohort of type 1 diabetes patients with at least 20 years duration of diabetes. Of the 460 patients from the original cohort still alive at 1 January 1994, all patients with a major first-time diabetes-related clinical event (limb amputation, blindness, stroke, cardiac event, or panretinal photocoagulation) and glycated haemoglobin (HbA(1c)) measurements before, 3 and/or 12 months after the event were included. Differences in HbA(1c) measurements before and after the event were tested with Wilcoxon's test. Results: A total of 64 patients with a major clinical event between 1994 and 2006 entered the study. Mean HbA(1c) measurements decreased from 8.8% at baseline to 8.6% at 3 months and 8.7% after 12 months, a non-significant decrease. In all event groups, glycaemic regulation was unaltered in the majority of the patients. Only a minority worsened or improved their regulation, and in all groups only non-significant changes were seen. Conclusions: Surprisingly, complication-related events did not improve glycaemic regulation in long-term type 1 diabetes patients. This is in contrast with the experience from other patient categories and shows how difficult it can be to alter glycaemic regulation in diabetes patients with stabilized disease. |
| Databáze: | OpenAIRE |
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