Ischemic Effects of Transcatheter Arterial Embolization with N-Butyl Cyanoacrylate-Lipiodol on the Colon in a Swine Model
| Autor: | Hiroki Minamiguchi, Shinya Sahara, Motoki Nakai, Shintaro Shirai, Tetsuo Sonomura, Kouhei Nakata, Ichiro Mori, Isao Takasaka, Akira Ikoma, Nobuyuki Kawai, Naohisa Sawa, Morio Sato |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Necrosis Colon Swine medicine.medical_treatment Infarction Risk Assessment Gastroenterology Statistics Nonparametric Catheterization Random Allocation Colon Sigmoid Ischemia Mesenteric Artery Superior Submucosa Internal medicine Animals Medicine Radiology Nuclear Medicine and imaging Embolization Probability urogenital system business.industry Arterial Embolization Biopsy Needle Rectum Vasa recta Enbucrilate medicine.disease Embolization Therapeutic Immunohistochemistry Surgery Disease Models Animal medicine.anatomical_structure Lipiodol Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug Artery |
| Zdroj: | CardioVascular and Interventional Radiology. 33:1009-1015 |
| ISSN: | 1432-086X 0174-1551 |
| Popis: | This study was designed to assess the safety of transcatheter arterial embolization (TAE) with n-butyl cyanoacrylate-lipiodol (NBCA-Lp) for the large bowel and to investigate the vital response to NBCA-Lp in a swine model. In nine swine, nine arteries nourishing the colon were embolized with NBCA-Lp (1 ml of NBCA mixed with 4 ml of lipiodol): sigmoid-rectal branch artery in six swine, right colic branch artery in two, and middle colic branch artery in one. The amount of NBCA-Lp was 0.1-0.4 ml. Sacrifice was conducted 3 days after TAE to identify histological infarction. Classification was conducted retrospectively: group A, vasa recta without NBCA-Lp embolization despite TAE; group B, three or fewer vasa recta with NBCA-Lp embolization; and group C, five or more vasa recta with NBCA-Lp embolization. In one swine in group A, no necrotic focus was observed. In group B, three of four swine experienced no ischemic damage. The remaining one swine experienced necrosis of mucosal and submucosal layers in one-fourth of the circumference. In group C, all four swine with marginal artery and five vasa recta or more embolized experienced total necrosis of mucosa, submucosa, and smooth muscle layers of the whole colonic circumference. Significant difference on the extent of ischemic damage was observed between groups B and C (P < 0.05). Microscopically, NBCA-Lp induced acute vasculitis. Embolization of three or fewer vasa recta with NBCA-Lp induced no ischemic damage or limited necrosis, whereas embolization of five or more vasa recta with NBCA-Lp induced extensive necrosis. |
| Databáze: | OpenAIRE |
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