Clinical course of patients with Behçet’s uveitis following discontinuation of infliximab therapy
| Autor: | Tatsushi Kawaguchi, Koju Kamoi, Hiroshi Takase, Manabu Mochizuki, Yuko Kawazoe, Masaru Miyanaga, Sunao Sugita |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Visual Acuity Behcet's disease Young Adult Internal medicine Humans Medicine Young adult skin and connective tissue diseases Adverse effect Retrospective Studies business.industry Behcet Syndrome Medical record Anti-Inflammatory Agents Non-Steroidal Antibodies Monoclonal Retrospective cohort study General Medicine Middle Aged medicine.disease Uveitis Anterior Infliximab Discontinuation stomatognathic diseases Ophthalmology Treatment Outcome Withholding Treatment Female business Uveitis medicine.drug |
| Zdroj: | Japanese Journal of Ophthalmology. 58:75-80 |
| ISSN: | 1613-2246 0021-5155 |
| DOI: | 10.1007/s10384-013-0283-3 |
| Popis: | To investigate the clinical course of Behcet’s uveitis patients following discontinuation of infliximab therapy. This retrospective chart review study examined Behcet’s disease patients who received infliximab treatment between 2000 and 2012. Medical records of patients whose infliximab treatment was discontinued were reviewed, with special focus on the frequency of uveitis attacks in the period before initiation, during treatment and after cessation of the infliximab therapy. Mean visual acuities were evaluated for each treatment period. Out of the 43 patients treated with infliximab at our uveitis clinic, ten were discontinued due to adverse events or inefficiency. Data for seven patients followed for more than 12 months before initiation and after cessation of infliximab were analyzed. Frequency of acute uveitis attacks was 7.43 per 12 months before initiation of infliximab, 2.86 during treatment and 0.57 after cessation. A statistically higher frequency of uveitis attacks was observed before initiation of infliximab compared to during (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink