Malignant biliary obstruction: clinical and histopathologic correlation after treatment with self-expanding metal prostheses
| Autor: | S Tatalovic, H Sulser, Christoph L. Zollikofer, Francesco Antonucci, L Boguth, M Heer |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Connective tissue Autopsy Neoplasms Mean Survival Time medicine Humans Radiology Nuclear Medicine and imaging In patient Aged Retrospective Studies Aged 80 and over Cholestasis business.industry Stent Histology Retrospective cohort study Prostheses and Implants Middle Aged equipment and supplies Surgery medicine.anatomical_structure Metals Female Stents Bile Ducts Radiology business After treatment |
| Zdroj: | Radiology. 192:669-674 |
| ISSN: | 1527-1315 0033-8419 |
| Popis: | To analyze clinical and autopsy findings in patients with malignant biliary obstruction treated with biliary endoprostheses.Stents were inserted endoscopically in nine patients and transhepatically in 50. In 24 patients, autopsy was performed; in 22 cases, histologic analysis of the area in which the stent was placed was available.The technical success rate was 100%, and the clinical success rate was 92%. Complications occurred in 16 patients, with one procedure-related death. The rate of severe complications was 19%, primarily due to acute cholangitis (n = 9). Mean survival time was 175 days. Stent obstruction was found in 12 patients and occurred on average 196 days after stent placement. Secondary treatment was successful in all 12 patients. Only one of 24 autopsy specimens demonstrated macroscopic nonobstructive tumor ingrowth. Histologic analysis showed that the main reaction to the stent was connective tissue formation, which never occurred before 3 months. Invasion by tumor cells was noted in only five cases.Tumor ingrowth is not a major cause of stent obstruction. |
| Databáze: | OpenAIRE |
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