THE EFFECT OF TRI‐POTASSIUM DI‐CITRATO BISMUTHATE (DE‐NOL) ON THE HEALING OF CHRONIC DUODENAL ULCERS
| Autor: | M. H. Alp, A. Kupa, G. P. Coughlin |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Placebo therapy medicine.medical_specialty Potassium chemistry.chemical_element Placebo Gastroenterology Placebos chemistry.chemical_compound Internal medicine medicine Humans Clinical Trials as Topic Wound Healing business.industry Bismuthate Chronic duodenal ulcer General Medicine Middle Aged Chronic disease chemistry Duodenal Ulcer Chronic Disease Female business Wound healing Bismuth After treatment |
| Zdroj: | Medical Journal of Australia. 1:294-298 |
| ISSN: | 1326-5377 0025-729X |
| DOI: | 10.5694/j.1326-5377.1977.tb130705.x |
| Popis: | Forty-six patients suffering from chronic duodenal ulcer, proven endoscopically, were treated in a randomized double-blind cross-over trial with either tri-potassium di-citrato bismuthate (De-Nol) or placebo for four weeks and assessed symptomatically and endoscopically. Those patients who failed to heal after treatment with either agent were crossed over to the alternative preparation and reassessed after a further 28 days. Forty-two patients completed the study involving 57 patient treatments. A highly significant improvement in both symptomatic response (P less than 0.01) and endoscopic healing (P less than 0.01) was seen in those patients receiving tri-potassium di-citrato bismuthate (De-Nol) as against placebo therapy. |
| Databáze: | OpenAIRE |
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