Synthesis and biological activity of 4'-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit

Autor:	Ivica Đilović, Zrinka Ivezić-Schoenfeld, Maja Matanović Škugor, Vlado Štimac, Hana Čipčić Paljetak, Dubravka Gembarovski, Đurdjica Lugarić, Stjepan Mutak, Darko Filic, David J. Holmes, Marina Modrić, Ivana Palej, Sulejman Alihodžić, Vesna Eraković Haber
Rok vydání:	2010
Předmět:	medicine.drug_class Stereochemistry Clinical Biochemistry Molecular Conformation Pharmaceutical Science Quinolones Biochemistry Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Drug Discovery medicine Humans Molecular Biology Antibacterial agent Bicyclic molecule Molecular Structure Organic Chemistry Drug Resistance Microbial Antimicrobial Quinolone Anti-Bacterial Agents chemistry macrolide quinolone antibacterial activity resistance Molecular Medicine Macrolides Antibacterial activity Linker Lead compound
Zdroj:	Bioorganicmedicinal chemistry. 18(17)
ISSN:	1464-3391
Popis:	The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quionolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural properties of lead compound 26 are discussed. Promising antibacterial properties of this compound and some of its analogues are reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1200b4b5908e0da0cb2f66bd7fa4fc https://pubmed.ncbi.nlm.nih.gov/20621489 Zobrazit plný text záznamu Full Text from ScienceDirect