Pulmonary hypertension as estimated by Doppler echocardiography in adolescent and adult patients with cystic fibrosis and their relationship with clinical, lung function and sleep findings

Autor: Simone Chaves Fagondes, Paulo de Tarso Roth Dalcin, Bruna Ziegler, Christiano Perin, Fernanda Cano Casarotto, Sérgio Saldanha Menna-Barreto
Rok vydání: 2016
Předmět:
Pulmonary and Respiratory Medicine
Adult
Male
Sleep Wake Disorders
medicine.medical_specialty
Adolescent
Cystic Fibrosis
Hypertension
Pulmonary
Polysomnography
030204 cardiovascular system & hematology
Risk Assessment
Severity of Illness Index
Statistics
Nonparametric
Hypoxemia
Pulmonary function testing
Pittsburgh Sleep Quality Index
Tertiary Care Centers
03 medical and health sciences
0302 clinical medicine
Sex Factors
Predictive Value of Tests
Internal medicine
medicine
Immunology and Allergy
Humans
Genetics (clinical)
Univariate analysis
Chi-Square Distribution
Exercise Tolerance
medicine.diagnostic_test
business.industry
Epworth Sleepiness Scale
Incidence
Age Factors
medicine.disease
Prognosis
Pulmonary hypertension
Echocardiography
Doppler
Respiratory Function Tests
Blood pressure
Cross-Sectional Studies
030228 respiratory system
Cardiology
Exercise Test
Female
medicine.symptom
business
Brazil
Zdroj: The clinical respiratory journal. 12(2)
ISSN: 1752-699X
Popis: BACKGROUND In cystic fibrosis (CF) patients, end stage of pulmonary disease is characterized by pulmonary hypertension (PH), hypoxemia, decrease in exercise tolerance, and sleep quality. OBJECTIVE To evaluate the association between clinical, lung function, sleep quality, and polysomnographic variables with PH in CF patients aged 16 years or older. METHODS In a cross-sectional study, 51 clinically stable CF patients underwent a clinical evaluation, an overnight polysomnography and answered sleep questionnaires (Pittsburgh Sleep Quality Index and Epworth sleepiness scale). Also, CF patients had their pulmonary function, 6-minute walk test (6MWT) and echocardiography assessed. RESULTS Fifty-one CF patients participated in the study; 47% were female. The mean age was 25.1 ± 8.8 years. Pulmonary artery systolic pressure (PASP) was greater than 35 mm Hg in 11 (27.5%) patients. Variables associated with PASP>35 mm Hg in univariate analysis were Shwachman-Kulczycki clinical score, forced expiratory volume in 1 second % of predicted, Pseudomonas aeruginosa in sputum culture, at-rest peripheral capillary oxygen saturation (SpO2 ), SpO2 at end of 6MWT and time of oxygen desaturation 35 mm Hg was at-rest SpO2 (OR = 10.8, CI 95% 1.7-67.3, P = .011). The cuttoff SpO2 < 94% had the sensitivity = 7/11 = 64%, specificity = 40/40 = 100%, positive predicted values = 7/7 = 100% and negative predicted values = 40/44 = 91% to the diagnosis of PH. CONCLUSION the present study showed a high rate of PH in adolescent and adult CF patients. At-rest SpO2 was associated with PH.
Databáze: OpenAIRE
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