Characteristics of Patients With Antiphospholipid Antibody Positivity in the APS ACTION International Clinical Database and Repository
Autor: | Jason S. Knight, Medha Barbhaiya, Hannah Cohen, Michelle Petri, Robert Roubey, Maria Efthymiou, Rohan Willis, Doruk Erkan, Vittorio Pengo, Esther Rodriguez, Amaia Ugarte, Ecem Sevim, Maria Laura Bertolaccini, Paul R. Fortin, H. Michael Belmont, Ricard Cervera, Diane Zisa, Lanlan Ji, Tatsuya Atsumi, Maria Gerosa, D. Ware Branch, Savino Sciascia, Aps Action Investigators, Guilherme Ramires de Jesus, Maria Angeles Aguirre Zamorano, Laura Andreoli, Maria G Tektonidou, Danieli Andrade |
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Rok vydání: | 2022 |
Předmět: |
Adult
Male medicine.medical_specialty Cohort Studies 03 medical and health sciences 0302 clinical medicine Rheumatology immune system diseases Antiphospholipid syndrome Internal medicine Humans Medicine Registries neoplasms 030203 arthritis & rheumatology biology Clinical events business.industry Middle Aged medicine.disease Clinical trial Baseline characteristics Cohort Antibodies Antiphospholipid biology.protein Female Anticardiolipin antibodies Core laboratory Antibody business |
Zdroj: | Arthritis Care & Research. 74:324-335 |
ISSN: | 2151-4658 2151-464X |
Popis: | To describe the baseline characteristics of patients with positivity for antiphospholipid antibodies (aPLs) who were enrolled in an international registry, the Antiphospholipid Syndrome (APS) Alliance for Clinical Trials and International Networking (APS ACTION) clinical database and repository, overall and by clinical and laboratory subtypes.The APS ACTION registry includes adults who persistently had positivity for aPLs. We evaluated baseline sociodemographic and aPL-related (APS classification criteria and "non-criteria") characteristics of patients overall and in subgroups (aPL-positive without APS, APS overall, thrombotic APS only, obstetric APS only, and both thrombotic APS/obstetric APS). We assessed baseline characteristics of patients tested for the presence of three aPLs (lupus anticoagulant [LAC] test, anticardiolipin antibody [aCL], and anti-βThe 804 aPL-positive patients assessed in the present study had a mean age of 45 ± 13 years, were 74% female, and 68% White; additionally, 36% had other systemic autoimmune diseases. Of these 804 aPL-positive patients, 80% were classified as having APS (with 55% having thrombotic APS, 9% obstetric APS, and 15% thrombotic APS/obstetric APS). In the overall cohort, 71% had vascular thrombosis, 50% with a history of pregnancy had obstetric morbidity, and 56% had experienced at least one non-criteria manifestation. Among those with three aPLs tested (n = 660), 42% were triple aPL-positive. While single-, double-, and triple aPL-positive subgroups had similar frequencies of vascular, obstetric, and non-criteria events, these events were lowest in the single aPL subgroup, which consisted of aCLs or anti-βOur study demonstrates the heterogeneity of aPL-related clinical manifestations and laboratory profiles in a multicenter international cohort. Within single aPL positivity, LAC may be a major contributor to clinical events. Future prospective analyses, using standardized core laboratory aPL tests, will help clarify aPL risk profiles and improve risk stratification. |
Databáze: | OpenAIRE |
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