Eosinophilic folliculitis of the scalp associated with PD-1/PDL1 inhibitors
| Autor: | Alfredo De Rossi, Marta Carlesimo, Giuseppe Soda, Maria Caterina Fortuna, Alessandro Federico, Gemma Caro, Francesca Magri, Ludovica De Vincentiis |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
scaring alopecia Programmed Cell Death 1 Receptor Folliculitis Dermatology folliculitis hair immune checkpoint nivolumab Eosinophilic folliculitis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Immune system Antigen medicine Humans Immune Checkpoint Inhibitors Scalp integumentary system business.industry Lichen Planus Alopecia Alopecia areata medicine.disease Immune checkpoint medicine.anatomical_structure 030220 oncology & carcinogenesis Nivolumab business |
| Zdroj: | Journal of cosmetic dermatologyREFERENCES. 19(12) |
| ISSN: | 1473-2165 |
| Popis: | Background Immune checkpoint inhibitors are monoclonal antibodies which target immune "checkpoints" enhancing T cell-mediated cytotoxic and antitumor responses. Together to the amazing results, these drugs are associated with some peculiar adverse events called immune-related adverse events. Alopecia is one of these. It is usually reported to be clinically and histologically similar to alopecia areata. Aims We report a case of eosinophilic folliculitis of the scalp occurred during nivolumab therapy, its management and some pathogenetic hypotheses. Patient Herein, we report the first case of eosinophilic folliculitis of the scalp occurred during nivolumab therapy, firstly appeared as a lichen planopilaris. Topical steroids and fusidic acid cream were applied with partial benefit and a scaring outcome. No discontinuation of nivolumab was required. Conclusion Immune checkpoint inhibitors induced inflammatory response leads to the exposure of hair follicle antigens and a consequent loss of Immuno Privilege. We hypothesize a role of steroids in deviating a primarily lichenoid reaction toward a folliculitis. |
| Databáze: | OpenAIRE |
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