The role of nutraceuticals as a complementary therapy against various neurodegenerative diseases: A mini-review

Autor: Hui-Fang Chiu, Chin-Kun Wang, Kamesh Venkatakrishnan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
MAPK
Mitogen-activated protein kinase
0211 other engineering and technologies
lcsh:Medicine
Complementary therapy
Review Article
02 engineering and technology
Disease
Resveratrol
AD
Alzheimer’s disease
Bioinformatics
01 natural sciences
Neuroprotection
Neuroprotective agents
SIRT1
Sirtuin 1
chemistry.chemical_compound
Nutraceutical
021105 building & construction
Medicine
Adverse effect
PD
Parkinson’s disease
NF-κB
Nuclear factor Kappa B
Coenzyme Q10
NDDs
neurodegenerative diseases
business.industry
Neurodegenerative diseases
lcsh:R
Nrf2
Nuclear factor-E2-related factor
PI3K
Phosphatidylinositol-3-kinase
BBB
Blood-brain barrier
HO-1
Heme Oxygenase-1
HD
Huntington’s disease
0104 chemical sciences
Clinical trial
JNK
c-Jun N-terminal Kinase
010404 medicinal & biomolecular chemistry
Complementary and alternative medicine
chemistry
ATP
Adenosine triphosphate
business
Zdroj: Journal of Traditional and Complementary Medicine, Vol 10, Iss 5, Pp 434-439 (2020)
Journal of Traditional and Complementary Medicine
ISSN: 2225-4110
Popis: In recent times, many scientists have given great attention to nutraceuticals (complementary medicine) as it widely used for promoting health status. In particular for the prevention and treatment of various neurological diseases or disorders without or less adverse effects. The current mini-review was intended to compile all popular (major) nutraceuticals against various neurodegenerative diseases (NDDs) including Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD) with special reference to clinical trials. Preliminary reviews indicated that nutraceuticals like curcumin, resveratrol, Epigallocatechin-3-gallate (EGCG), Coenzyme Q10, ω-3 FA (DHA/EPA/ALA), showed better neuroprotective activity against various NDDs in human setting (clinical trial). Hence this contribution will focus only on those popular nutraceuticals with proposed brief mechanisms (antioxidant, anti-inflammatory, mitochondrial homeostasis, autophagy regulation, promote neurogenesis) and its recommendation. This mini-review would aid common people to choose better nutraceuticals to combat various NDDs along with standard neuroprotective agents and modified lifestyle pattern.
Graphical abstract Image 1
Databáze: OpenAIRE
Externí odkaz: