Mucosal immune responses in four distinct compartments of women infected with human immunodeficiency virus type 1: a comparison by site and correlation with clinical information
| Autor: | Karl V. Sitz, Merlin L. Robb, Deborah L. Birx, Andrew W. Artenstein, Abby F. Rogers, Robin P. Garner, John W. Byron, Steven C. D. Veit, Kenneth F. Wagner, Paul R. Burnett, Thomas C. VanCott |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Immunoglobulin A
Adult Saliva Immunoglobulins HIV Infections Cervix Uteri HIV Antibodies Immunoglobulin G HIV Envelope Protein gp160 Immune system Immunity Immunopathology medicine Immunology and Allergy Humans Parotid Gland Immunity Mucosal Immunodeficiency Aged biology virus diseases Genitalia Female Middle Aged medicine.disease Nasal Mucosa Infectious Diseases Immunoglobulin M Immunology biology.protein HIV-1 Female Antibody |
| Zdroj: | The Journal of infectious diseases. 175(2) |
| ISSN: | 0022-1899 |
| Popis: | Because mucosal immune responses may be important in protection against human immunodeficiency virus type 1 (HIV-1), HIV-1-specific immune responses at mucosal sites in natural infection were compared. Total antibody concentrations and HIV-1-specific binding antibody responses in four distinct mucosal sites and serum were assessed in 41 HIV-infected and 19 HIV-seronegative women. HIV-1 gp160-specific IgG responses were detected in >99% of mucosal samples in infected subjects, with the highest titers in genital secretions. HIV-1-specific IgA was detected in the majority of endocervical secretions (94%) and nasal washes (95%) but less often in vaginal washes (51%) and parotid saliva (38%). There was no significant correlation between mucosal immune response and most clinical factors. Based on methodologic considerations, frequencies of detection, and HIV-1-specific responses, nasal washes and genital secretions may each provide important measures of HIV-1-specific mucosal immune responses in infected women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|