Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels
| Autor: | Robert Szulcek, Charissa E. van den Brom, Christa Boer, Peter L. Hordijk, Nicole A M Dekker, Jisca Majolée, Willem W. J. van Strien, Anoek L I van Leeuwen, Alexander B.A. Vonk |
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| Přispěvatelé: | Anesthesiology, ACS - Microcirculation, Physiology, ACS - Atherosclerosis & ischemic syndromes, Pulmonary medicine, Cardio-thoracic surgery, ACS - Heart failure & arrhythmias, IOO, ACS - Diabetes & metabolism |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Vascular permeability Kidney Critical Care and Intensive Care Medicine law.invention Microcirculation Angiopoietin-2 03 medical and health sciences 0302 clinical medicine law In vivo Internal medicine Angiopoietin-1 Cardiopulmonary bypass Humans Medicine Lung Aged biology business.industry Research lcsh:Medical emergencies. Critical care. Intensive care. First aid Endothelial Cells 030208 emergency & critical care medicine lcsh:RC86-88.9 Middle Aged Receptor TIE-2 Angiopoietin receptor Cardiac surgery surgical procedures operative medicine.anatomical_structure Cardiology biology.protein Female business Biomarkers Capillary permeability circulatory and respiratory physiology Artery |
| Zdroj: | Critical Care, 23(1):117. Springer Science + Business Media Dekker, N A M, van Leeuwen, A L I, van Strien, W W J, Majolée, J, Szulcek, R, Vonk, A B A, Hordijk, P L, Boer, C & van den Brom, C E 2019, ' Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels ', Critical Care, vol. 23, no. 1, 117 . https://doi.org/10.1186/s13054-019-2418-5 Critical Care, Vol 23, Iss 1, Pp 1-10 (2019) Critical Care |
| ISSN: | 1364-8535 |
| DOI: | 10.1186/s13054-019-2418-5 |
| Popis: | Background Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcirculatory perfusion and angiopoietin-2 levels in patients after CPB. Methods Clinical data, sublingual microcirculatory data, and plasma samples were collected from patients undergoing coronary artery bypass graft surgery with CPB (n = 17) before and at several time points up to 72 h after CPB. Renal and pulmonary microvascular endothelial cells were incubated with patient plasma, and in vitro endothelial barrier function was assessed using electric cell–substrate impedance sensing. Plasma levels of angiopoietin-1,-2, and soluble Tie2 were measured, and the association with in vitro endothelial barrier function and in vivo microcirculatory perfusion was determined. Results A plasma-induced reduction of renal and pulmonary endothelial barrier function was observed in all samples taken within the first three postoperative days (P |
| Databáze: | OpenAIRE |
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