Sickle cell disease is associated with iron mediated hypercoagulability
| Autor: | Vance G. Nielsen, Wayne K. Jacobsen, Nirmish Shah, Martha A. Fielder, Ian J. Welsby |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Iron Overload Adolescent Iron Cell Disease Anemia Sickle Cell Fibrinogen Gastroenterology IRB Approval Thrombin hemic and lymphatic diseases Internal medicine medicine Humans Thrombophilia Child Blood Coagulation Hematology business.industry Coagulation kinetics medicine.anatomical_structure Coagulation Child Preschool Immunology Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of thrombosis and thrombolysis. 40(2) |
| ISSN: | 1573-742X |
| Popis: | Sickle cell disease (SCD) is associated with a significant hypercoagulable state and several hemostatic anomalies have been identified in this disease state. Of interest, SCD patients can become iron overloaded after transfusion, and iron can enhance fibrinogen as a substrate for thrombin, resulting in thrombi that commence coagulation quickly and form rapidly. We hypothesized that SCD patients would display hypercoagulable plasma coagulation kinetics and an iron enhancement of coagulation. After obtaining IRB approval, we assessed coagulation kinetics and iron enhancement with viscoelastic methods in archived, citrated plasma obtained from ambulatory or hospitalized SCD patients (n = 20). All SCD patients had plasmatic hypercoagulability, and 65 % were positive for iron enhancement of coagulation. In conclusion, continuing investigation correlating such viscoelastic data with clinical symptoms may provide insight into the role played by iron in the setting of SCD, including complications such as vaso-occlusive crisis. |
| Databáze: | OpenAIRE |
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