Local cytokine changes in complex regional pain syndrome type I (CRPS I) resolve after 6 months
| Autor: | Claudia Sommer, Ana Maria Waaga-Gasser, Nurcan Üçeyler, Elena K. Krumova, Melanie Lenz, Martin Tegenthoff, Jule Frettlöh, Annika Reinersmann, P. Stude, Oliver Höffken, Silke Lissek, Christoph Maier |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Eotaxin Chemokine Time Factors medicine.medical_treatment Analgesic Proinflammatory cytokine medicine Humans Prospective Studies Aged Pain Measurement biology business.industry Middle Aged medicine.disease Reflex Sympathetic Dystrophy Anesthesiology and Pain Medicine Complex regional pain syndrome Cytokine Neurology Immunology Neuropathic pain biology.protein Cytokines Female Tumor necrosis factor alpha Neurology (clinical) business Biomarkers |
| Zdroj: | Pain. 154:2142-2149 |
| ISSN: | 0304-3959 |
| DOI: | 10.1016/j.pain.2013.06.039 |
| Popis: | There is evidence that inflammatory processes are involved in at least the early phase of complex regional pain syndrome (CRPS). We compared a panel of pro- and antiinflammatory cytokines in skin blister fluids and serum from patients with CRPS and patients with upper-limb pain of other origin (non-CRPS) in the early stage (< 1 year) and after 6 months of pain treatment. Blister fluid was collected from the affected and contralateral nonaffected side. We used a multiplex-10 bead array cytokine assay and Luminex technology to measure protein concentrations of the cytokines interleukin-1 receptor antagonist (IL-1RA), IL-2, IL-6, IL-8, IL-10, IL-12p40, and tumor necrosis factor-alpha (TNF-α) and the chemokines eotaxin, monocyte chemotactic protein-1 (MCP-1), and macrophage inflammatory protein-1β (MIP-1β). We found bilaterally increased proinflammatory TNF-α and MIP-1β and decreased antiinflammatory IL-1RA protein levels in CRPS patients compared to non-CRPS patients. Neither group showed side differences. After 6 months under analgesic treatment, protein levels of all measured cytokines in CRPS patients, except for IL-6, significantly changed bilaterally to the level of non-CRPS patients. These changes were not related to treatment outcome. In serum, only IL-8, TNF-α, eotaxin, MCP-1, and MIP-1β were detectable without intergroup differences. Blister fluid of CRPS patients showed a bilateral proinflammatory cytokine profile. This profile seems to be relevant only at the early stage of CRPS. Almost all measured cytokine levels were comparable to those of non-CRPS patients after 6 months of analgesic treatment and were not related to treatment outcome. |
| Databáze: | OpenAIRE |
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