Mechanism underlying gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats
| Autor: | Masayuki Kimura, Katsuo Kamata, Kazuhito Hayakawa |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Agonist
Male medicine.medical_specialty Baclofen Time Factors medicine.drug_class Systole Blood Pressure In Vitro Techniques Rats Inbred WKY Methoxamine GABA Antagonists chemistry.chemical_compound Species Specificity Internal medicine Rats Inbred SHR medicine Animals Vasoconstrictor Agents Receptor GABA Agonists Antihypertensive Agents gamma-Aminobutyric Acid Pharmacology Dose-Response Relationship Drug Muscimol Bicuculline Receptor antagonist Mesenteric Arteries Rats Endocrinology Blood pressure nervous system chemistry Vasoconstriction Saclofen medicine.drug |
| Zdroj: | European journal of pharmacology. 438(1-2) |
| ISSN: | 0014-2999 |
| Popis: | We examined the effects of gamma-aminobutyric acid (GABA) on the blood pressure in spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. A single oral administration (0.5 mg/kg) significantly lowered the systolic blood pressure in spontaneously hypertensive rats, but not in normotensive rats. In the mesenteric arterial bed, the perivascular nerve stimulation-induced increase in perfusion pressure and noradrenaline release were significantly inhibited by GABA in spontaneously hypertensive rats, but not in normotensive rats, and attenuated by the selective GABA(B) receptor agonist, baclofen, but not by the selective GABA(A) receptor agonist muscimol. The inhibitory effects of GABA on the perivascular nerve stimulation-induced increase in perfusion pressure and noradrenaline release were completely antagonized by the selective GABA(B) receptor antagonist, saclofen, but not by the selective GABA(A) receptor antagonist, bicuculline. These results suggest that, in spontaneously hypertensive rats, GABA has an antihypertensive effect due to its inhibition of noradrenaline release from sympathetic nerves in the mesenteric arterial bed via presynaptic GABA(B) receptors. |
| Databáze: | OpenAIRE |
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