Adipose tissue isomeric trans fatty acids and risk of myocardial infarction in nine countries: the EURAMIC study

Autor:	J. Ringstad, P. van 't Veer, Jeremy D. Kark, Frans J. Kok, Antti Aro, B.C. Martin, R.A. Riemersma, V.P. Mazaev, J M Martin-Moreno, J. Gomez-Aracena, A.F.M. Kardinaal, Miguel Delgado-Rodríguez, I Salminen, J. K. Huttunen, Lenore Kohlmeier, Michael Thamm
Přispěvatelé:	Centraal Instituut voor Voedingsonderzoek TNO, University of Zurich, Aro, A
Rok vydání:	1995
Předmět:	Adult Male medicine.medical_specialty Myocardial Infarction Adipose tissue 610 Medicine & health Coronary Disease 2700 General Medicine Isomerism Risk Factors Internal medicine Odds Ratio medicine Humans Life Science Myocardial infarction Israel Risk factor Biology Aged VLAG chemistry.chemical_classification business.industry Fatty Acids Vakgroep Gezondheidsleer Case-control study Fatty acid 10060 Epidemiology Biostatistics and Prevention Institute (EBPI) General Medicine Odds ratio Middle Aged medicine.disease Dietary Fats Environmental and Occupational Health Group Coronary heart disease Diet Surgery Europe Endocrinology Adipose Tissue chemistry Quartile Case-Control Studies business
Zdroj:	The Lancet, 345, 273-278 The Lancet 345 (1995) Lancet, 8945, 345, 273-278
ISSN:	0140-6736
DOI:	10.1016/s0140-6736(95)90273-2
Popis:	Dietary isomeric trans fatty acids-mainly produced by hydrogenation of oils-are suspected of increasing the risk of coronary heart disease. Dietary trans fatty acid intake is reflected in the fatty acid composition of adipose tissue. In an international multicentre study in eight European countries and Israel (EURAMIC), adipose tissue aspiration samples were obtained from 671 men with acute myocardial infarction (AMI), aged 70 years or less, and 717 men without a history of AMI (controls). The proportion of fatty acids, including isomeric trans monoenoic fatty acids with 18 carbon atoms (C18:1), was determined by gas chromatography. Although there were considerable differences between countries in mean (SD) proportion of adipose tissue C18:1 trans fatty acids, there was no overall difference between cases (1.61 [0.92]%) and the controls (1.57 [0.86]%). The risk of AMI did not differ significantly from 1.0 over quartiles of adipose C18:1 trans fatty acids: the multivariate odds ratio was 0.97 (95% CI 0.56-1.67) for the highest versus lowest quartile. After exclusion of subjects from Spanish centres because they had far lower proportions of adipose trans fatty acids than subjects from other countries, there was a tendency to increased risk of AMI in the upper quartiles of C18:1 trans; however, the trend was not statistically significant. Our results reflect considerable differences between countries in dietary intake of trans fatty acids but do not suggest a major overall effect of C18:1 trans fatty acids on risk of AMI. We cannot exclude the possibility that trans fatty acids have a significant impact on risk of AMI in populations with high intake.
Databáze:	OpenAIRE
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