Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs
| Autor: | Mark R. Crowley, Jeffrey R. Fineman, Scott J. Soifer |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
inorganic chemicals
Pulmonary Circulation Physiology Hypertension Pulmonary Rest Blood Pressure Vasodilation Thromboxane A2 chemistry.chemical_compound Adenosine Triphosphate Left atrial Physiology (medical) High doses medicine Animals Hypoxia Sheep business.industry Hypoxia (medical) medicine.disease Pulmonary hypertension Prostaglandin Endoperoxides Synthetic Blood pressure Animals Newborn chemistry 15-Hydroxy-11 alpha 9 alpha-(epoxymethano)prosta-5 13-dienoic Acid Anesthesia medicine.symptom business Pulmonary vasodilators |
| Zdroj: | Journal of Applied Physiology. 69:1836-1842 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1990.69.5.1836 |
| Popis: | We investigated the effects of infusions of ATP-MgCl2 on the circulation in 11 spontaneously breathing newborn lambs during pulmonary hypertension induced either by the infusion of U-46619, a thromboxane A2 mimetic, or by hypoxia. During pulmonary hypertension induced by U-46619, ATP-MgCl2 (0.01-1.0 mg.kg-1.min-1) caused a significant dose-dependent decrease in pulmonary arterial pressure (12.4-40.7%, P less than 0.05), while systemic arterial pressure decreased only at the highest doses (P less than 0.05). Left atrial infusions of ATP-MgCl2 caused systemic hypotension without decreasing pulmonary arterial pressure. During hypoxia-induced pulmonary hypertension, ATP-MgCl2 caused a similar significant dose-dependent decrease in pulmonary arterial pressure (12.0-41.1%, P less than 0.05), while systemic arterial pressure decreased only at high doses (P less than 0.05). Regression analysis showed selectivity of the vasodilating effects of ATP-MgCl2 for the pulmonary circulation during pulmonary hypertension induced either by U-46619 or hypoxia. ATP-MgCl2 is a potent vasodilator with a rapid metabolism that allows for selective vasodilation of the vascular bed first encountered (pulmonary or systemic). We conclude that infusions of ATP-MgCl2 may be clinically useful in the treatment of children with pulmonary hypertension. |
| Databáze: | OpenAIRE |
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