Inflammatory and endothelial markers during the menstrual cycle

Autor:	Roza Chaireti, Katarina Bremme, Birgitta Byström, Tomas L. Lindahl, Anders Larsson
Rok vydání:	2016
Předmět:	0301 basic medicine Adult medicine.medical_specialty endocrine system media_common.quotation_subject Clinical Biochemistry Inflammation Luteal phase Luteal Phase menstrual cycle pentraxin 03 medical and health sciences Young Adult 0302 clinical medicine Sex hormone-binding globulin Internal medicine Sex Hormone-Binding Globulin Follicular phase Medicine Humans Young adult reproductive and urinary physiology Menstrual cycle media_common 030219 obstetrics & reproductive medicine biology business.industry Klinisk medicin General Medicine Inflammatory mediator 030104 developmental biology Endocrinology Follicular Phase biology.protein Female medicine.symptom Clinical Medicine Inflammation Mediators business Biomarkers
Zdroj:	Scandinavian journal of clinical and laboratory investigation. 76(3)
ISSN:	1502-7686
Popis:	Background The menstrual cycle exhibits a pattern of repeated inflammatory activity. The present study aims to evaluate inflammatory and endothelial markers during the two phases of a menstrual cycle. Methods The study cohort consisted of 102 women with regular menstrual cycles. Inflammatory and endothelial markers (interleukin-6 [IL-6], pentraxin-3 [PTX-3], hs-C reactive protein [hs-CRP], sE-selectin, sP-selectin, intracellular and vascular cell adhesion molecules [ICAM-1 and VCAM-1] and cathepsins L, B and S) were measured during the early follicular and the late luteal phase of a normal menstrual cycle. Results Pentraxin-3 (PTX-3) and hs-CRP were significantly higher during the follicular phase compared to the luteal phase (p < 0.001 respectively p = 0.025). The other inflammatory and endothelial markers, with the exception of cathepsin B, were higher, albeit not significantly, during the follicular phase. Conclusions Inflammatory activity, expressed mainly by members of the pentraxin family, is higher during the early follicular compared to the luteal phase. This could be associated to menstruation but the exact mechanisms behind this pattern are unclear and might involve the ovarian hormones or an effect on hepatocytes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ff6a402acfe41e8428fd5aa82340e1 https://pubmed.ncbi.nlm.nih.gov/26963835 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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