Effects of probiotic and prebiotic supplementation on metabolic parameters, liver aminotransferases, and systemic inflammation in nonalcoholic fatty liver disease: A randomized clinical trial

Autor: Shima Jazayeri, M J Zahedi, Vahideh Behrouz, Naheed Aryaeian
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
030309 nutrition & dietetics
medicine.medical_treatment
Placebo
digestive system
Gastroenterology
law.invention
03 medical and health sciences
Probiotic
chemistry.chemical_compound
0404 agricultural biotechnology
law
Weight loss
Non-alcoholic Fatty Liver Disease
Internal medicine
Nonalcoholic fatty liver disease
medicine
Humans
Transaminases
Triglycerides
0303 health sciences
medicine.diagnostic_test
Triglyceride
business.industry
Prebiotic
Probiotics
04 agricultural and veterinary sciences
Cholesterol
LDL
gamma-Glutamyltransferase
Middle Aged
medicine.disease
Alkaline Phosphatase
040401 food science
Lipids
digestive system diseases
C-Reactive Protein
Prebiotics
chemistry
Liver
Alkaline phosphatase
Female
medicine.symptom
Lipid profile
business
Food Science
Zdroj: Journal of food scienceREFERENCES. 85(10)
ISSN: 1750-3841
Popis: This study aimed to evaluate the clinical efficacy of probiotic and prebiotic supplementation on the metabolic parameters, liver enzymes, and inflammation in patients with nonalcoholic fatty liver disease (NAFLD). In this study, patients with NAFLD were assigned to receive either probiotic capsule + placebo of prebiotic (probiotic group), oligofructose + placebo of probiotic (prebiotic group), or placebo of probiotic + placebo of prebiotic (control group) for 12 weeks. All participants followed a weight loss diet and physical activity recommendation during intervention. Anthropometric measurements decreased in all three groups, but there was no significant difference among groups. Probiotic supplementation was able to decrease triglyceride, alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), and alkaline phosphatase compared to control group. The serum levels of triglyceride, total and low-density lipoprotein cholesterol, ALT, AST, and GGT differed significantly in prebiotic group in comparison to the placebo. High-sensitive C-reactive protein significantly decreased within all groups; however, there was no significant difference among groups after intervention. Probiotic and prebiotic may be beneficial in improving liver enzymes and lipid profile in patients with NAFLD.
Databáze: OpenAIRE
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