Gene expression and morphometric parameters of human bone biopsies after maxillary sinus floor elevation with autologous bone combined with Bio-Oss® or BoneCeramic®
| Autor: | Jorge Caubet, Mikel Ramos-Murguialday, Marta Monjo, Miguel Á. Morey, Joana M. Ramis |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Sinus Floor Augmentation Bone Regeneration Maxillary sinus medicine.medical_treatment Biopsy Dentistry Core Binding Factor Alpha 1 Subunit Osteogenesis medicine Maxilla Humans Dental implant Bone regeneration Minerals Bone Transplantation medicine.diagnostic_test business.industry BoneCeramic Maxillary Sinus Middle Aged medicine.anatomical_structure Bone Substitutes Female Implant Hydroxyapatites Oral Surgery business |
| Zdroj: | Clinical oral implants research. 26(6) |
| ISSN: | 1600-0501 |
| Popis: | Objectives: Although the clinical success of Bio-Oss and BoneCeramic has been corroborated by histologic and histomorphometric findings, the biological events that occur during healing after maxillary sinus floor elevation (MSFE) are unknown. Here, we evaluated biopsies of grafted bone with a mixture of autologous bone and Bio-Oss or BoneCeramic after two different healing time periods to understand the molecular process underlying bone formation after MSFE. Material and methods: Seven patients, following a bilateral split-mouth design model and needing a MSFE to allow implant placement, were recruited for this study. Right or left sinuses were grafted with autologous maxillary bone combined either with Bio-Oss or BoneCeramic, respectively. Twenty biopsies were taken at the time of implant insertion after 4–5 months or 6– 8 months of MSFE, and analyzed by micro-computed tomography (microCT) and gene-expression analysis. Results: MicroCT analysis revealed no differences in the morphometric parameters or BMD either after 4–5 months or 6–8 months of MSFE between Bio-Oss and BoneCeramic. At molecular level, a higher expression of bone forming gene Runx2 was observed after 4–5 months of MSFE in the Bio-Oss compared with the BoneCeramic group. Conclusions: Our results indicate that differences found at the molecular level between Bio-Oss and BoneCeramic are not translated to important differences in the 3D microstructure and BMD of the grafted bone. Maxillary sinus floor elevation (MSFE) aims at achieving a bone volume sufficient for the insertion of endosseous implants in those patients with insufficient bone volume condition. During the procedure, a door hinge in the lateral side of the maxillary sinus wall is |
| Databáze: | OpenAIRE |
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