Coffee prevents fatty liver disease induced by a high-fat diet by modulating pathways of the gut-liver axis

Autor:	G. Mazzone, Antonella Rossi, Nicola Caporaso, Giuseppe D'Argenio, Danilo Ercolini, Paola Vitaglione, Vincenzo Lembo, Marcella Savoia, Ilario Mennella, Federico Salomone, Filomena Morisco, Francesca De Filippis, Maria Guido
Přispěvatelé:	Vitaglione, P., Mazzone, G., Lembo, V., D'Argenio, G., Rossi, A., Guido, M., Savoia, M., Salomone, F., Mennella, I., De Filippis, F., Ercolini, D., Caporaso, N., Morisco, F.
Rok vydání:	2018
Předmět:	Male ALT Endocrinology Diabetes and Metabolism ABCA1 Feces Mice 0302 clinical medicine ATP-binding cassette subfamily G1 LXR-α liver X receptor-α Non-alcoholic steatohepatitis chemistry.chemical_classification digestive oral and skin physiology HFD plus decaffeinated coffee FFAR free fatty acid receptor high-fat diet Cholesterol standard diet Free fatty acid receptor free fatty acid receptor 030211 gastroenterology & hepatology zonulin-1 ACOX1 medicine.medical_specialty ABCA1 ATP-binding cassette subfamily A1 Gut microbiota Diet High-Fat 03 medical and health sciences NAFLD ATP-binding cassette subfamily A1 PPAR alpha RNA Messenger Protein Precursors Gut permeability SD ZO-1 zonulin-1 Fatty acid nutritional and metabolic diseases Polyphenols ABCG1 ATP-binding cassette subfamily G1 ACOX1 acyl-CoA oxidase 1 ALT alanine aminotransferase HFD+COFFEE HFD plus decaffeinated coffee HFD high-fat diet Metabolic syndrome NAFLD non-alcoholic fatty liver disease PYY peptide YY SD standard diet medicine.disease Mice Inbred C57BL 030104 developmental biology Endocrinology chemistry Peptide YY Claudins HFD Acyl-CoA Oxidase Non-alcoholic steatohepatiti 0301 basic medicine Blood Glucose LXR-α Gut flora Coffee chemistry.chemical_compound Non-alcoholic Fatty Liver Disease peptide YY ZO-1 ATP Binding Cassette Transporter Subfamily G Member 1 Metabolic Syndrome Nutrition and Dietetics biology Fatty liver Alanine Transaminase Intestines Liver lipids (amino acids peptides and proteins) ATP Binding Cassette Transporter 1 Research Article ABCG1 alanine aminotransferase FFAR liver X receptor-α Internal medicine medicine Animals acyl-CoA oxidase 1 HFD+COFFEE PYY Haptoglobins business.industry biology.organism_classification Gastrointestinal Microbiome Dietary Supplements business Food Science Alcaligenaceae
Zdroj:	Journal of Nutritional Science
ISSN:	2048-6790
Popis:	Coffee consumption is inversely associated with the risk of non-alcoholic fatty liver disease (NAFLD). A gap in the literature still exists concerning the intestinal mechanisms that are involved in the protective effect of coffee consumption towards NAFLD. In this study, twenty-four C57BL/6J mice were divided into three groups each receiving a standard diet, a high-fat diet (HFD) or an HFD plus decaffeinated coffee (HFD+COFFEE) for 12 weeks. Coffee supplementation reduced HFD-induced liver macrovesicular steatosis (P P P PPAR- α(P P ABCA1) and subfamily G1 (ABCG1) (P P P P Alcaligenaceaein the faeces (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fa3a4662d50c4106f4ab69ef6c926e https://pubmed.ncbi.nlm.nih.gov/31037218 Zobrazit plný text záznamu